Hyperbaric oxygen treatment in a rare complication of intramuscular injection: four cases of Nicolau syndrome

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dc.contributor.authorKorpinar, Sefika
dc.date.accessioned2025-01-27T20:27:38Z
dc.date.available2025-01-27T20:27:38Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntramuscular injections are one of the most common clinical procedures. The objectives of this case series are to analyse the role, timing and efficacy of hyperbaric oxygen treatment (HBOT) in the management of Nicolau syndrome (NS), an extremely rare complication of this common intervention. Clinical, demographic, laboratory and microbiological data extraction were performed through retrospective analysis of the medical records of all patients with NS who were referred for HBOT over a 10-year period with wounds, ischaemia, infection or necrosis at the injection site following drug injection; four patients with NS were included. All injections were made via the intramuscular route; three adult cases followed a non-steroidal anti-inflammatory drug, diclofenac sodium and one in a child followed penicillin injection. The time between diagnosis/injection and HBOT ranged from five to 33 days. NS can develop despite all preventive measures based on injection technique guidelines. HBOT appeared beneficial to healing of NS when administered with other therapeutic approaches. Due to the missing pieces of the puzzle in pathogenesis, NS is rarely completely reversible; keeping the awareness high for undesirable complications stands out as the most effective approach.
dc.identifier.doi10.28920/dhm52.2.149-153
dc.identifier.endpage153
dc.identifier.issn1833-3516
dc.identifier.issue2
dc.identifier.pmid35732287
dc.identifier.scopus2-s2.0-85132619344
dc.identifier.scopusqualityQ3
dc.identifier.startpage149
dc.identifier.urihttps://doi.org/10.28920/dhm52.2.149-153
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22741
dc.identifier.volume52
dc.identifier.wosWOS:000823676900011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSouth Pacific Underwater Med Soc
dc.relation.ispartofDiving and Hyperbaric Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCase reports
dc.subjectEmbolia cutis medicamentosa
dc.subjectNicolau syndrome
dc.subjectNon-steroidal anti-inflammatories
dc.subjectWounds
dc.titleHyperbaric oxygen treatment in a rare complication of intramuscular injection: four cases of Nicolau syndrome
dc.typeArticle

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