Safety of bioabsorbable implants in vitro

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dc.authoridISYAR, Mehmet/0000-0001-9052-4411
dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.contributor.authorIsyar, Mehmet
dc.contributor.authorYilmaz, Ibrahim
dc.contributor.authorNusran, Gurdal
dc.contributor.authorGuler, Olcay
dc.contributor.authorYalcin, Sercan
dc.contributor.authorMahirogullari, Mahir
dc.date.accessioned2025-01-27T20:16:50Z
dc.date.available2025-01-27T20:16:50Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The aim of the present study was to investigate the safety of bioabsorbable plates and screws in humans. Methods: For this purpose, an implant system based on [poly(lactic-co-glycolic acids)(85: 15)] was designed. The system was tested for pH, temperature, and swelling and then its surface morphology was analyzed for surface porosity using environmental electron microscopy. Then, the effects of this bioabsorbable system on the viability and profileration of osteocytes were examined on a molecular level via in vitro experiments. A [poly(lactic-co-glycolic acids)(90:10)] bioabsorbable implant, which is commercially available and used in orthopedic surgery, was used as control group. For the statistical evaluation of the data obtained in the present study, the groups were compared by Tukey HSD test following ANOVA. The significance level was set as p < 0.05. Results: It was observed that the osteocytes cultivated on the PLGA system designed in the present study included more live cells and allowed more proliferation compared to the control. Conclusion: One of the criteria in the selection of implants for orthopedic surgery is that a good implant should not need removal and thus a second surgery. In the present study, a bioabsorbable implant was designed considering this criterion. The present study is the first step to prove the safety of this new design by in vitro toxicity and viability experiments.
dc.identifier.doi10.1186/s12893-015-0111-4
dc.identifier.issn1471-2482
dc.identifier.pmid26652613
dc.identifier.scopus2-s2.0-84960427550
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12893-015-0111-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21408
dc.identifier.volume15
dc.identifier.wosWOS:000366364300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBioabsorbable implant
dc.subjectosteocyte proliferation
dc.subjectosteoblastic activity
dc.subjectpoly(lactic-co-glycolic acids)
dc.titleSafety of bioabsorbable implants in vitro
dc.typeArticle

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