Glucose-Induced Alteration of Accumulation of Organotechnetium Complexes Accumulation in Pgp-Negative Tumor-Bearing Mice

Basit Öğe Kaydı
dc.contributor.authorUstun, Funda
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorCukur, Ziya
dc.contributor.authorAltaner, Semsi
dc.contributor.authorBerkarda, Sakir
dc.date.accessioned2025-01-27T20:16:59Z
dc.date.available2025-01-27T20:16:59Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe biologic and microenvironmental factors determining (99m)Tc sestamibi (MIBI) and (99m)Tc tetrofosmin (TF) uptake in breast tumors are incompletely understood, especially in P-glycoprotein (Pgp)-negative tumors. We analyzed the influence of glucose administration on the uptake and retention of MIBI and TF in Pgp-negative tumor-bearing mice in vivo. Twenty (20) mice bearing Ehrlich ascites tumor cell (EATC) xenografts were divided into four groups: (1) MIBI, (2) MIBI+glucose, (3) TF, and (4) TF+glucose. Glucose was administered (5.0 g/kg body weight) intraperitoreally (i.p.) 1 hour before scintigraphy. There were significant differences between the E-UPR MIBI and MIBI+glucose groups (p = 0.009) and minor differences in L-UPR between these groups (p = 0.04). There was a significant inverse correlation between E-UPR of MIBI and glucose levels (r = 0.71, p = 0.02). Comparing the four groups, the highest E-UPR was obtained in the MIBI group (p = 0.006). Other parameters were not different in the MIBI and MIBI+glucose groups and in the TF and TF+glucose groups. Increased blood glucose level affected the MIBI uptake of tumor tissue, particularly for E-UPR. We suggest that these findings were due to basically decreased blood flow and secondarily decreased extracellular pH. However, glucose administration did not affect TF.
dc.identifier.doi10.1089/cbr.2008.0546
dc.identifier.endpage338
dc.identifier.issn1084-9785
dc.identifier.issue3
dc.identifier.pmid19538056
dc.identifier.scopus2-s2.0-67650803447
dc.identifier.scopusqualityQ1
dc.identifier.startpage333
dc.identifier.urihttps://doi.org/10.1089/cbr.2008.0546
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21453
dc.identifier.volume24
dc.identifier.wosWOS:000267205100006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticals
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectEATC
dc.subjectglucose
dc.subjectMIBI
dc.subjecttetrofosmin
dc.titleGlucose-Induced Alteration of Accumulation of Organotechnetium Complexes Accumulation in Pgp-Negative Tumor-Bearing Mice
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu