FT-Raman, FT-IR, NMR structural characterization and antimicrobial activities of 1,6-bis(benzimidazol-2-yl)-3,4-dithiahexane ligand and its Hg(II) halide complexes

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.contributor.authorAghatabay, Naz Mohammed
dc.contributor.authorTulu, Metin
dc.contributor.authorMahmiani, Yaghub
dc.contributor.authorSomer, Mehmet
dc.contributor.authorDulger, Basaran
dc.date.accessioned2025-01-27T21:04:16Z
dc.date.available2025-01-27T21:04:16Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstract1,6-Bis(benzimidaz-2-yi)-3,4-dithiahexane ligand (L) and its mercury halide complexes were prepared and characterised. The elemental analysis, molecular conductivity, FT-Raman, FT-IR (mid, far), H-1, C-13 NMR and geometry optimization in MOPAC using MNDOd parameter on CACHE, prove the existence of neutral, mononuclear and the distorted tetrahedral [Hg(L)X-2] complexes. In all the three complexes, the ligand acts as a chelating bidentate, through two of the bridging sulphur atoms and together with the monodentate coordination of the two anionic halide ligands to the metal centre forming a possible 4-coordinate compounds. The antimicrobial activities of free ligand, its hydrochlorinated salt, mercury halides and the complexes are evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against 10 bacteria. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of Penicillin-g, Ampicillin, Cefotaxime, Vancomycin, onaxacin and Tetracyclin well-known antibacterial agents. The results from dilution procedure are compared with Gentamycin as antibacterial and Nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii and Hanseniaspora guillierinondii, and the results are referenced with Nystatin, Ketaconazole and Clotrimazole, commercial antifungal agents. In most cases, the compounds show broad-spectrum (Gram(+) & Gram(-) bacteria) activities that are comparatively, slightly less active or equipotent to the antibiotic and antifungal agents in the comparison tests.
dc.identifier.doi10.1007/s11224-007-9253-z
dc.identifier.endpage80
dc.identifier.issn1040-0400
dc.identifier.issn1572-9001
dc.identifier.issue1
dc.identifier.scopus2-s2.0-43049125494
dc.identifier.scopusqualityQ2
dc.identifier.startpage71
dc.identifier.urihttps://doi.org/10.1007/s11224-007-9253-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27596
dc.identifier.volume19
dc.identifier.wosWOS:000255750500011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofStructural Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectantimicrobial
dc.subjectbidentate
dc.subjectchelating
dc.subjectdisk diffusion
dc.subjectgentamycin
dc.subjectRaman
dc.titleFT-Raman, FT-IR, NMR structural characterization and antimicrobial activities of 1,6-bis(benzimidazol-2-yl)-3,4-dithiahexane ligand and its Hg(II) halide complexes
dc.typeArticle

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