Comprehensive Mapping of Psychosocial Burden in Breast Cancer: A Multicenter Cross-Sectional Study in Türkiye

Aim: This study aimed to investigate the sociodemographic and clinical factors associated with depression and anxiety in women diagnosed with breast cancer and to identify predictors that may contribute to psychological distress.Materials and Methods: This multicenter cross-sectional study included 460 breast cancer patients assessed via structured interviews and medical records. Depression and anxiety symptoms were measured using validated tools (Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7), with scores >= 10 indicating clinical significance. Logistic regression analyses identified independent predictors.Results: Clinically significant depression and anxiety were observed in 24.6% and 27.2% of the participants, respectively. Depression was independently associated with younger age [adjusted odds ratio (AOR): 4.68], being childless (AOR: 2.47), low income (AOR: 3.35), limited healthcare access (AOR: 3.34), and low social support (AOR: 6.38). Clinical predictors included premenopausal status (AOR: 2.86), poor sleep (AOR: 2.18), lymphedema (AOR: 2.55), advanced cancer stage (AOR: 1.65), and active chemotherapy (AOR: 2.61). Anxiety was similarly linked to younger age (AOR: 2.93), poor access to care (AOR: 3.84), low social support (AOR: 4.34), and ongoing treatments including chemotherapy and hormone therapy.Conclusion: Depression and anxiety are prevalent among breast cancer patients and are strongly associated with both sociodemographic disadvantages and clinical disease burden. Routine psychological screening should be integrated into oncology care to support patient well-being and optimize outcomes