Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity

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dc.authoridCiftci, Halilibrahim/0000-0002-9796-7669
dc.authoridEllakwa, Doha/0000-0003-4824-3485
dc.authoridFujita, Mikako/0000-0001-6705-4052
dc.authoridOral, Ayhan/0000-0003-4965-8754
dc.authorid, Mohamed/0000-0002-9220-2659
dc.contributor.authorCiftci, Halil, I
dc.contributor.authorCan, Mustafa
dc.contributor.authorEllakwa, Doha E.
dc.contributor.authorSuner, Salih C.
dc.contributor.authorIbrahim, Mohamed A.
dc.contributor.authorOral, Ayhan
dc.contributor.authorSekeroglu, Nazim
dc.date.accessioned2025-01-27T20:20:40Z
dc.date.available2025-01-27T20:20:40Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMarine natural products have drawn a great deal of attention as a vital source of new drugs for the last five decades. However, marine organisms in the seas surrounding Turkey (the Black Sea, the Aegean Sea and the Mediterranean Sea) haven't been yet extensively explored. In the present study, three marine organisms (Dysidea avara, Microcosmus sabatieri and Echinaster sepositus) were sampled from the Dardanelles (Turkish Straits System, Western Turkey) by scientific divers, transferred to the laboratory and then were extracted with 70% ethanol. The extracts were tested for their cytotoxic effect against K562, KMS-12PE, A549, and A375 cancer cell lines. The sponge extract elicited the most promising cytotoxic activity, thus it was further evaluated against H929, MCF-7, HeLa, and HCT116 cancer cells. Most of the designated cells showed a considerable sensitivity for the sponge extract particularly H929, K562, KMS-12PE and HeLa cells with IC50 less than 10 mu g/mL. On the contrary, the other two extracts exhibited no cytotoxic activity on all cells at 100 mu g/mL concentration. The sponge extract was tested for its capacity to induce apoptosis in cancer cells and to inhibit a panel of tyrosine kinases showing remarkable results. The outcome of this study represents a platform for discovery of new chemotherapeutic agents of marine natural origin.
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [221S0001]; Science Farm Ltd.; Izmir Katip Celebi University grants commision [2019-ONAP-SUUF0002]; [24659048]; Grants-in-Aid for Scientific Research [20H03365] Funding Source: KAKEN
dc.description.sponsorshipWe are grateful to the Screening Committee of Anticancer Drugs supported by a Grant-in-Aid for Scientific Research on Innovative Areas, Scientific Support Programs for Cancer Research (No. 221S0001), from The Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), for assistance with the evaluation of compounds. This work was supported by a Grant for Joint Research Project with Science Farm Ltd. The study was also supported in part by a Grant-in-Aid for Challenging Exploratory Research to M.O. (24659048). We are grateful for the support from Izmir Katip Celebi University grants commision (project number: 2019-ONAP-SUUF0002)
dc.identifier.doi10.1007/s10637-020-00911-8
dc.identifier.endpage1333
dc.identifier.issn0167-6997
dc.identifier.issn1573-0646
dc.identifier.issue5
dc.identifier.pmid32062733
dc.identifier.scopus2-s2.0-85079719943
dc.identifier.scopusqualityQ1
dc.identifier.startpage1326
dc.identifier.urihttps://doi.org/10.1007/s10637-020-00911-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21782
dc.identifier.volume38
dc.identifier.wosWOS:000516185300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInvestigational New Drugs
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMarine products
dc.subjectCancer
dc.subjectApoptosis
dc.subjectTyrosine kinase inhibitors
dc.titleAnticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity
dc.typeArticle

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