Targeted GC-MS analysis of firefighters' exhaled breath: Exploring biomarker response at the individual level

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dc.authoridHorn, Gavin/0000-0002-4364-9673
dc.authoridMentese, Sibel/0000-0002-0395-3603
dc.authoridPleil, Joachim/0000-0001-8211-0796
dc.contributor.authorWallace, M. Ariel Geer
dc.contributor.authorPleil, Joachim D.
dc.contributor.authorOliver, Karen D.
dc.contributor.authorWhitaker, Donald A.
dc.contributor.authorMentese, Sibel
dc.contributor.authorFent, Kenneth W.
dc.contributor.authorHorn, Gavin P.
dc.date.accessioned2025-01-27T21:05:26Z
dc.date.available2025-01-27T21:05:26Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBiomarker measurements can provide unambiguous evidence of environmental exposures as well as the resultant biological responses. Firefighters have a high rate of occupational cancer incidence, which has been proposed to be linked in part to their increased environmental exposure to byproducts of combustion and contaminants produced during fire responses. In this article, the uptake and elimination of targeted volatile organic compounds were investigated by collecting the exhaled breath of firefighters on sorbent tubes before and after controlled structure burns and analyzing samples using automated thermal desorption-gas chromatography (ATD-GC/MS). Volatile organic compounds exposure was assessed by grouping the data according to firefighting job positions as well as visualizing the data at the level of the individual firefighter to determine which individuals had expected exposure responses. When data were assessed at the group level, benzene concentrations were found to be elevated post-exposure in both fire attack, victim search, and outside ventilation firefighting positions. However, the results of the data analysis at the individual level indicate that certain firefighters may be more susceptible to post-exposure volatile organic compounds increases than others, and this should be considered when assessing the effectiveness of firefighting protective gear. Although this work focuses on firefighting activity, the results can be translated to potential human health and ecological effects from building and forest fires.
dc.description.sponsorshipU.S. Department of Homeland Security Assistance to Firefighters Grant Fire Prevention Safety program [EMW-2013-FP-00766]; TUBITAK
dc.description.sponsorshipNIOSH and the University of Illinois Institutional Review Boards approved this study, which was funded by the U.S. Department of Homeland Security Assistance to Firefighters Grant Fire Prevention & Safety program (EMW-2013-FP-00766). This study was also conducted through partnership with the CDC Foundation. Dr. Sibel Mentese is grateful for the travel grant received from TUBITAK.
dc.identifier.doi10.1080/15459624.2019.1588973
dc.identifier.endpage366
dc.identifier.issn1545-9624
dc.identifier.issn1545-9632
dc.identifier.issue5
dc.identifier.pmid30932751
dc.identifier.scopus2-s2.0-85063669204
dc.identifier.scopusqualityQ2
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.1080/15459624.2019.1588973
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27643
dc.identifier.volume16
dc.identifier.wosWOS:000465794300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Occupational and Environmental Hygiene
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBenzene
dc.subjectenvironment
dc.subjectoccupational exposure
dc.subjectself-contained breathing apparatus (SCBA)
dc.subjectthermal desorption (TD)
dc.subjectvolatile organic compounds (VOCs)
dc.titleTargeted GC-MS analysis of firefighters' exhaled breath: Exploring biomarker response at the individual level
dc.typeArticle

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