Evaluation of Serum Tumor Necrosis Factor-alpha-Induced Adipose-Associated Protein (TIARP/STEAP4) Level and Its Association with Disease Activity in Patients with Psoriasis: ASingle-Center Prospective Comparative Study

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dc.contributor.authorKaya, Ozge
dc.contributor.authorKeskinkaya, Zeynep
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorMermutlu, Selda Isik
dc.contributor.authorKilic, Sevilay Oguz
dc.date.accessioned2025-01-27T20:52:19Z
dc.date.available2025-01-27T20:52:19Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Tumor necrosis factor-alpha (TNF-alpha)-induced adipose-associated protein (TIARP/STEAP4) is a protective metalloreductase against oxidative stress that is induced by various proinflammatory cytokines, including TNF-alpha and interleukin-17. This study aimed to evaluate whether STEAP4 is elevated in patients with psoriasis and whether it is associated with disease activity. Materials and Methods: In this prospective cross-sectional single-center study, serum STEAP4 levels measured by the ELISA method in serum samples collected from psoriasis patients and healthy individuals. The association between STEAP4 levels and demographic characteristics and clinical findings in patients with psoriasis was further evaluated. Results: Forty-one psoriasis patients with a female: male ratio of 1:1 and a median age of 44 years and 40 controls were included in the study. The median STEAP4 level of the patients with psoriasis (9.25) was significantly higher than that of the control group (1.04) (P < 0.001). Although STEAP4 levels did not differ significantly in patients with psoriasis regarding sex, joint, and nail involvement, no significant correlation was found with age, age at disease onset, disease duration, and severity. Conclusion: The high levels of STEAP4 detected in patients with psoriasis might reflect its anti-inflammatory effects on Th-1 and Th-17 responses and on neutrophil and macrophage infiltration. On the other hand, a possible genetic variation or defect at the receptor level for STEAP4 in patients with psoriasis might hamper an adequate anti-inflammatory effect and lead to increased STEAP4 expression as a compensation mechanism. The present study not only indicates that STEAP4 might play a role in the pathogenesis of psoriasis but also suggests potential implications for its role in treatment and follow-up, which offers a promising direction for further investigation.
dc.description.sponsorshipanakkale Onsekiz Mart University Scientific Research Projects Unit as an independent research project [THD-2022-3941]
dc.description.sponsorshipThis study was supported financially by the Canakkale Onsekiz Mart University Scientific Research Projects Unit as an independent research project (project number: THD-2022-3941) .
dc.identifier.doi10.4274/tjd.galenos.2024.19484
dc.identifier.endpage124
dc.identifier.issn1307-7635
dc.identifier.issn1308-5255
dc.identifier.issue4
dc.identifier.startpage119
dc.identifier.urihttps://doi.org/10.4274/tjd.galenos.2024.19484
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25731
dc.identifier.volume18
dc.identifier.wosWOS:001396789500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurk Dermatoloji Dergisi-Turkish Journal of Dermatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPsoriasis
dc.subjectinflammation
dc.subjectTIARP
dc.subjectSTEAP4
dc.titleEvaluation of Serum Tumor Necrosis Factor-alpha-Induced Adipose-Associated Protein (TIARP/STEAP4) Level and Its Association with Disease Activity in Patients with Psoriasis: ASingle-Center Prospective Comparative Study
dc.typeArticle

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