Recurrent Pregnancy Loss and Its Relation to Combined Parental Thrombophilic Gene Mutations

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dc.authoridCetin, Ali/0000-0002-5767-7894
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorYenicesu, Gonca Imir
dc.contributor.authorSilan, Fatma
dc.contributor.authorKoksal, Binnur
dc.contributor.authorAtik, Sinem
dc.contributor.authorOzen, Filiz
dc.contributor.authorGol, Mert
dc.date.accessioned2025-01-27T20:29:36Z
dc.date.available2025-01-27T20:29:36Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and Aim: Recurrent pregnancy loss (RPL) is a heterogeneous disorder that has been associated with antiphospholipid syndrome and other prothrombotic parameters. We aimed to investigate the prevalence of 12 thrombophilic gene mutations in RPL couples in the current results. Method: In a total of 543 Turkish women with RPL and 327 of their male partners (870 individuals with RPL), and a control group of 106 fertile couples (control) were analyzed for factor V leiden (FVL), factor V H1299R, factor II prothrombin G20210A, FXIII V34L, b-fibrinogen -455G>A, plasminogen activator inhibitor-1 (PAI-1), GPIIIa L33P (HPA-1 a/b L33P), methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, ACE I/D, Apo B R3500Q, and Apo E genes. Results: The overall, heterozygous and/or homozygous point mutations in FVL -FVR2, ApoE2, PAI-1, MTHFR C677T - A1298C, and ACE genes were associated with RPL. There was no meaningful association between RPL and other studied genes. Conclusion: The homozygosity of 4G in PAI-1 and MTHFR C677T genes in women with RPL, and heterozygosity of FVL, FVR2, ACE, and ApoE2 genes in both parents play crucial role in RPL and should be considered as a risk factor in RPL. Current results showed that RPL is related to combined parental (not only maternal) thrombophilic gene mutations.
dc.identifier.doi10.1089/gtmb.2011.0191
dc.identifier.endpage286
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue4
dc.identifier.pmid22047507
dc.identifier.scopus2-s2.0-84860197151
dc.identifier.scopusqualityQ3
dc.identifier.startpage279
dc.identifier.urihttps://doi.org/10.1089/gtmb.2011.0191
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22991
dc.identifier.volume16
dc.identifier.wosWOS:000303109400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectFactor-V-Leiden
dc.subjectMethylenetetrahydrofolate Reductase C677t
dc.subjectCoronary-Artery-Disease
dc.subjectProtein-C Resistance
dc.subjectPlasminogen-Activator
dc.subjectFactor-Xiii
dc.subjectRisk-Factors
dc.subjectMyocardial-Infarction
dc.subjectCommon Polymorphisms
dc.subject4g/5g Polymorphism
dc.titleRecurrent Pregnancy Loss and Its Relation to Combined Parental Thrombophilic Gene Mutations
dc.typeArticle

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