The impact of neuropsychiatric burden on Restless Legs Syndrome (RLS) disease severity

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dc.contributor.authorKılınçarslan, Mehmet Göktuğ
dc.contributor.authorOcak, Özgül
dc.contributor.authorŞahin, Erkan Melih
dc.date.accessioned2025-01-27T21:04:08Z
dc.date.available2025-01-27T21:04:08Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: In patients with Restless Legs Syndrome (RLS), neuropsychiatric comorbidities like anxiety, depression, and somatization are common, yet the precise connection between somatization and RLS severity remains unclear. This study aims to elucidate the influence of neuropsychiatric comorbidities on RLS severity, focusing particularly on the role of somatization. Methods: This cross-sectional analytical study was conducted at a tertiary hospital. All 113 RLS patients who followed in neurology clinic for at least a year were invited, and 87 participated. Data collection included sociodemographic details, the International Restless Legs Syndrome Study Group rating scale (IRLS), the Beck Depression Inventory, Beck Anxiety Scale, and Somatization Scale. Elastic-net regularized path analysis was used as the statistical method. Results: Among the 87 participants (70.1 % female, mean age 52.5 +/- 13.2 years), the mean duration of RLS diagnosis was 4.95 +/- 4.53 years. Univariate statistics revealed positive correlations among RLS severity, anxiety, depression, and somatization. Path analysis showed that somatization was associated with RLS severity (p = 0.014). Anxiety had no direct effect on RLS severity but influenced it indirectly through its positive association with somatization (p < 0.001). Depression was found to have no effect on RLS severity, either directly or through somatization. Conclusions: The relationship between anxiety and RLS severity is mediated by somatization. Furthermore, the association between RLS severity and somatization appears to be more significant than previously recognized, highlighting the importance of considering somatization in addressing the neuropsychiatric burden of RLS patients.
dc.identifier.doi10.1016/j.sleep.2024.12.004
dc.identifier.endpage87
dc.identifier.issn1389-9457
dc.identifier.issn1878-5506
dc.identifier.pmid39647326
dc.identifier.scopus2-s2.0-85211058658
dc.identifier.scopusqualityQ1
dc.identifier.startpage82
dc.identifier.urihttps://doi.org/10.1016/j.sleep.2024.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27562
dc.identifier.volume126
dc.identifier.wosWOS:001378862900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKılınçarslan, Mehmet Göktuğ
dc.institutionauthorOcak, Özgül
dc.institutionauthorŞahin, Erkan Melih
dc.institutionauthorid0000-0003-4197-1914
dc.institutionauthorid0000-0001-8276-0174
dc.institutionauthorid0000-0003-1520-8464
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSleep Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectRestless legs syndrome
dc.subjectSomatic symptoms
dc.subjectAnxiety
dc.subjectDepression
dc.subjectMediating factors
dc.titleThe impact of neuropsychiatric burden on Restless Legs Syndrome (RLS) disease severity
dc.typeArticle

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