HISTOPATHOLOGICAL AND SCINTIGRAPHIC COMPARISONS OF THE PROTECTIVE EFFECTS OF l-CARNITINE AND AMIFOSTINE AGAINST RADIATION-INDUCED LATE RENAL TOXICITY IN RATS

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dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridPARLAR, SULE/0000-0001-9422-853X
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.contributor.authorCaloglu, Murat
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorOz-Puyan, Fulya
dc.contributor.authorUstun, Funda
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorSaynak, Mert
dc.date.accessioned2025-01-27T20:38:56Z
dc.date.available2025-01-27T20:38:56Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of the present study was to compare the protective effects of l-carnitine and amifostine against radiation-induced late nephrotoxicity using technetium-99m diethylenetriaminepentaacetic acid scintigraphy and histopathological examination. Seventy-one Albino rats were randomly divided into six groups as follows: (i) AMI + RAD (n = 15), 200 mg/kg, i.p., amifostine 30 min prior to irradiation (a single dose of 9 Gy); (ii) LC + RAD (n = 15), 300 mg/kg, i.p., l-carnitine 30 min prior to irradiation; (iii) LC (n = 10), 300 mg/kg, i.p., l-carnitine 30 min prior to sham irradiation; (iv) AMI (n = 10), 200 mg/kg, i.p., amifostine 30 min prior to sham irradiation; RAD (n = 11), 1 mL/kg, i.p., normal saline 30 min prior to irradiation; and (vi) control (n = 10), 1 mL/kg, i.p., normal saline 30 min prior to sham irradiation. Scintigraphy was performed before treatment and again 6 months after treatment. Kidneys were examined by light microscopy and a histopathological scoring system was used to assess the degree of renal damage. The main histopathological findings were proximal tubular damage and interstitial fibrosis. Glomerular injury was similar in all groups. Tubular degeneration and atrophy were less common in the AMI + RAD group than in the RAD group (P = 0.011 and P = 0.015, respectively), as well as in the LC + RAD group compared with the RAD group (P = 0.028 and P = 0.036, respectively). Interstitial fibrosis in the AMI + RAD and LC + RAD groups was significantly less than that in the RAD group (P = 0.015 and P = 0.015, respectively). The highest total renal injury score (9) was seen in the RAD group. On scintigraphy, there were significant differences in post-treatment time to peak count (T(max)) and time from peak count to half count (T(1/2)) values (P = 0.01 and 0.02, respectively) between groups in the right kidney. In the control and RAD groups, the T(1/2) of the right kidney was 8 +/- 2 and 21 +/- 2 min, respectively. The T(max) values for the AMI + RAD and LC + RAD groups (2.8 +/- 0.2 and 3.2 +/- 0.2 min, respectively) were similar to those in the control group (2.5 +/- 0.3 min). Based on the results of the present study, l-carnitine and amifostine have comparable and significant protective effects against radiation-induced late nephrotoxicity.
dc.identifier.doi10.1111/j.1440-1681.2008.05103.x
dc.identifier.endpage530
dc.identifier.issn0305-1870
dc.identifier.issue5-6
dc.identifier.pmid19673935
dc.identifier.scopus2-s2.0-65349172318
dc.identifier.scopusqualityQ2
dc.identifier.startpage523
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2008.05103.x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23809
dc.identifier.volume36
dc.identifier.wosWOS:000265549200011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofClinical and Experimental Pharmacology and Physiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectamifostine
dc.subjectl-carnitine
dc.subjecthistopathology
dc.subjectkidney
dc.subjectnephrotoxicity
dc.subjectradiation
dc.subjectradioprotection
dc.subjectrat
dc.subjectscintigraphy
dc.titleHISTOPATHOLOGICAL AND SCINTIGRAPHIC COMPARISONS OF THE PROTECTIVE EFFECTS OF l-CARNITINE AND AMIFOSTINE AGAINST RADIATION-INDUCED LATE RENAL TOXICITY IN RATS
dc.typeArticle

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