Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes

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dc.authoridYalcin, Hulya/0000-0003-1717-3242
dc.contributor.authorColak, Ayfer
dc.contributor.authorAkinci, Baris
dc.contributor.authorDiniz, Gulden
dc.contributor.authorTurkon, Hakan
dc.contributor.authorErgonen, Faruk
dc.contributor.authorYalcin, Hulya
dc.contributor.authorCoker, Isil
dc.date.accessioned2025-01-27T20:38:50Z
dc.date.available2025-01-27T20:38:50Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground/aims. In this present study, we aimed: (i) To clarify if prediabetes is associated with subclinical inflammation independent of underlying obesity, and (ii) to evaluate the effect of postload glucose concentration on subclinical inflammation markers in a group of patients with elevated fasting glucose. Material and methods. In a cohort of 165 patients with newly detected fasting hyperglycemia, according to 75 g oral glucose tolerance test (OGTT), subjects were classified either as newly diagnosed type 2 diabetes (diabetes group, n = 40), impaired fasting glucose (IFG) plus impaired glucose tolerance (IGT) (IFG/IGT group, n = 42) or IFG only (IFG group, n = 83). A control group (n = 47) consisted of age-and body mass index (BMI)-matched healthy subjects with a normal OGTT. Circulating concentrations of lipids, insulin, interleukin-6 (IL-6), interleukin-8 (IL-8) and high sensitive C-reactive protein (hsCRP) were measured. HOMA index was calculated. Results. Subclinical inflammation markers were elevated in patients with diabetes and IFG/IGT compared to healthy controls and also IFG patients (diabetes vs. control: p < 0.05 for hsCRP, IL-8, and IL-6; IFG/IGT vs. control: p < 0.05 for hsCRP, and IL-6; diabetes vs. IFG: p < 0.05 for hsCRP, and IL-6; IFG/IGT vs. IFG: p < 0.05 for hsCRP, and IL-6). In multiple regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (p < 0.05 for hsCRP, and IL-6). Conclusion. Our results suggest that patients with prediabetes, independent of underlying obesity, have increased concentrations of subclinical inflammation which is mostly driven by postload glucose concentrations.
dc.identifier.doi10.3109/00365513.2013.798870
dc.identifier.endpage427
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue5
dc.identifier.pmid23767858
dc.identifier.scopus2-s2.0-84882356289
dc.identifier.scopusqualityQ3
dc.identifier.startpage422
dc.identifier.urihttps://doi.org/10.3109/00365513.2013.798870
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23770
dc.identifier.volume73
dc.identifier.wosWOS:000323106700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofScandinavian Journal of Clinical & Laboratory Investigation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDiabetes mellitus
dc.subjectoral glucose tolerance test
dc.subjectprediabetic state
dc.subjectinterleukin-6
dc.subjectinterleukin-8
dc.subjectC-reactive protein
dc.titlePostload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes
dc.typeArticle

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