Effects of Supplementation with Iron, Selenium and Magnesium on Galleria mellonella Cell-Mediated Immune Responses

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dc.contributor.authorKaya, Serhat
dc.contributor.authorGündüz, Bülent
dc.date.accessioned2025-01-27T19:30:43Z
dc.date.available2025-01-27T19:30:43Z
dc.date.issued2021
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractImmune responses play a key role in the survival of all living things. Intake of inorganic materials is ofcritical importance in living organisms because of their participation in metabolism and some component ofcells. Iron (Fe), magnesium (Mg) and selenium (Se) were selected for this study because of their participation incritical constituents of cells, such as nucleic acids and enzymes in living organisms, and their indirect and directeffects on immunity. Although the separate effects of these inorganic materials are known, there is no study ontheir combined effects. Galleria mellonella, which is used as a model organism, is frequently used in evaluatingof effects of human pathogens due to its various properties. Total hemocyte counts and encapsulationmelanization responses are the most commonly observed parameters when examining the immune responsesof this model organism. In our study, the effects of the selected inorganic materials added in the ratio of 0.1%,0.25%, 0.5% and 1% in the nutrient content of G. mellonella on the immune responses of this organism wereinvestigated. As a result of the study, it was found that only 0.25% of the doses increased the hemocyte countand that the other doses significantly decreased compared to the control group. However, it was determinedthat 0.5% and 1% feeding caused a significant decrease in both hemocyte count and encapsulationmelanization responses. According to our findings, the nutrients which have over a certain dose by inorganicsubstances have negative effects on immunity.
dc.identifier.doi10.30910/turkjans.911913
dc.identifier.endpage614
dc.identifier.issn2148-3647
dc.identifier.issue3
dc.identifier.startpage605
dc.identifier.trdizinid440671
dc.identifier.urihttps://doi.org/10.30910/turkjans.911913
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/440671
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16230
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Tarım ve Doğa Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectGenetik ve Kalıtım
dc.subjectİmmünoloji
dc.titleEffects of Supplementation with Iron, Selenium and Magnesium on Galleria mellonella Cell-Mediated Immune Responses
dc.typeArticle

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