Green synthesized silver nanoparticles based on N-3-(dimethylamino)propyl methacrylamide/2-hydroxyethyl methacrylate hydrogels for antibacterial wound dressing material

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dc.authoridÖzay, Özgür/0000-0001-6589-9844
dc.contributor.authorSeref, Elif
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:45:27Z
dc.date.available2025-01-27T20:45:27Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, hydrogels were synthesized using Prunus persica ev. Bayrami & ccedil; Beyaz & imath; extract as a crosslinker. N-3-(Dimethylamino)propyl methacrylamide (DMAPMA) and 2-Hydroxyethyl methacrylate (HEMA) monomers were used in hydrogels synthesized by redox polymerization. Hydrogel@Ag composites were created by synthesizing Ag-0 nanoparticles within hydrogel network structures cross-linked with plant extract using an in-situ green synthesis method. These hydrogels and composites were characterized by swelling, FTIR, TEM, XRD, TGA methods. The synthesized hydrogels and hydrogel@Ag composites were loaded with Naproxen and Cefazolin drugs. The in-vitro drug release profiles of the hydrogels were examined in a pH = 5.5 and PBS environment, and it was determined that approximately 75% of the drugs were released within 5 h. The release kinetics model for the hydrogels was the Higuchi model, followed by the Korsmeyer-Peppas model. Ag-0 nanoparticle encapsulation significantly affected the degree of swelling. The hydrogel cross-linked with MBA showed a swelling capacity of 370.16% by mass, while the hydrogel cross-linked with fruit extract exhibited a swelling capacity of 1000.78% by mass. The silver-encapsulated hydrogel demonstrated an even higher swelling capacity of 2313% by mass. Additionally, antibacterial tests against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis microorganisms, showed that Ag-free hydrogels did not exhibit antibacterial activity. [GRAPHICS] .
dc.description.sponsorshipCanakkale Onsekiz Mart University, Scientific Research Coordination Unit [FYL-2024- 4594]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University, Scientific Research Coordination Unit (Project number: FYL-2024- 4594).
dc.identifier.doi10.1080/10601325.2024.2393599
dc.identifier.endpage690
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85201945783
dc.identifier.scopusqualityQ2
dc.identifier.startpage675
dc.identifier.urihttps://doi.org/10.1080/10601325.2024.2393599
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24578
dc.identifier.volume61
dc.identifier.wosWOS:001297875200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHydrogel
dc.subjectgreen synthesis
dc.subjectwound dressing
dc.subjectantibacteriel material
dc.subjectnanoparticle
dc.titleGreen synthesized silver nanoparticles based on N-3-(dimethylamino)propyl methacrylamide/2-hydroxyethyl methacrylate hydrogels for antibacterial wound dressing material
dc.typeArticle

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