The Radio-protective effects of Caffeic Acid Phenethyl Ester and Thymoquinone in rats exposed to total head irradiation

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dc.authoridDIRIL, Halit/0000-0003-4409-8268
dc.authoridtarakcioglu, mehmet/0000-0002-2398-8264
dc.contributor.authorCikman, Oztekin
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorGulsen, Murat Taner
dc.contributor.authorDemir, Elif
dc.contributor.authorAkan, Muslum
dc.contributor.authorDiril, Halit
dc.contributor.authorKiraz, Hasan Ali
dc.date.accessioned2025-01-27T20:57:52Z
dc.date.available2025-01-27T20:57:52Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMany cancer patients treated with radiotherapy suffer severe side effects during and after their treatment. The aim of this study was to investigate the effects of irradiation and the addition of caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ) on the oxidant/antioxidant system in the liver tissue of irradiated rats. A total of 40 Sprague-Dawley rats were divided into five groups to test the radioprotective effectiveness of thymoquinone and caffeic acid phenethyl ester administered by intraperitoneal injection. Appropriate control groups were also studied. While liver tissue total oxidant status, lipid hydroperoxide level, and oxidative stress index were significantly increased in the irradiated (IR) group, compared with other groups, total antioxidant status, sulfhydryl levels, and paraoxonase (PON) activity were significantly decreased. Ceruloplasmin activity in IR plus TQ and IR groups was higher than the control group. Arylesterase and PON activities in IR plus TQ- and IR plus CAPE-supplemented groups were lower than those of control groups. TQ and CAPE decrease oxidative stress markers and have antioxidant effects, which also augment antioxidant capacity in the liver tissue of irradiated rats.
dc.identifier.doi10.1007/s00508-014-0635-0
dc.identifier.endpage108
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue3-4
dc.identifier.pmid25409943
dc.identifier.scopus2-s2.0-84925506821
dc.identifier.scopusqualityQ1
dc.identifier.startpage103
dc.identifier.urihttps://doi.org/10.1007/s00508-014-0635-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26529
dc.identifier.volume127
dc.identifier.wosWOS:000350688200004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCaffeic acid phenethyl ester
dc.subjectThymoquinone
dc.subjectIrradiation
dc.subjectFree radicals
dc.subjectTotal oxidant status
dc.subjectTotal antioxidant status
dc.subjectOxidative stress index
dc.titleThe Radio-protective effects of Caffeic Acid Phenethyl Ester and Thymoquinone in rats exposed to total head irradiation
dc.title.alternativeRadioprotektive Wirkung von Kaffeesäurephenylethylester und Thymoquinon gegen oxidativen Stress im Lebergewebe von Ratten nach Exposition einer Gesamtschädelbestrahlung
dc.typeArticle

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