The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants

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dc.authoridAnnakkaya, Ali Nihat/0000-0002-7661-8830
dc.contributor.authorUyrum, Ebru
dc.contributor.authorBalbay, Oner
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorBalbay, Ege Gulec
dc.contributor.authorSılan, Fatma
dc.contributor.authorArbak, Peri
dc.date.accessioned2025-01-27T20:14:22Z
dc.date.available2025-01-27T20:14:22Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Clinical and epidemiological studies indicate that obstructive sleep apnea syndrome (OSAS) has a strong genetic basis. Objectives: To investigate the apolipoprotein E (APOE) alleles as a genetic risk factor in OSAS. Methods: A total of 73 patients (37 male) were included. All underwent full-night polysomnography and were evaluated for APOE alleles. Results: The mean age was 51 +/- 12 years. Forty-two of the patients had OSAS. The APOE3 allele was found in 97.3% (71/73) of the study population. The most common APOE genotype was E3/E3 (55/73, 75.3%). Compared to the individuals with no APOE2 alleles (E3/E3, E3/E4), the individuals with at least one APOE2 allele (E2/E3, E2/E4) had a 9.37-fold greater OSAS risk (OR = 9.37, 95% CI 1.13-77.7, p = 0.019). The individuals with APOE2 alleles (E2/E3, E2/E4) compared to the individuals with only an E3/E3 allele genotype had a 10-fold greater OSAS risk (OR = 10.3, 95% CI 1.24-86.61, p = 0.0308). Compared to the individuals with no APOE4 alleles (E2/E3, E3/E3), the individuals with APOE4 alleles (E2/E4, E3/E4) had a high but insignificant risk for OSAS (OR = 2.9, 95% CI 0.55-15.05, p = 0.286). The individuals with APOE4 alleles (E2/E4, E3/E4) compared to APOE3 alleles (E3/E3) had an increased but insignificant risk for OSAS (OR = 3.62, 95% CI 0.96-19.05, p = 0.127). Conclusion: Specific APOE genotypes are associated with OSAS in a high-risk population. (C) 2015 S. Karger AG, Basel
dc.identifier.doi10.1159/000369560
dc.identifier.endpage200
dc.identifier.issn0025-7931
dc.identifier.issn1423-0356
dc.identifier.issue3
dc.identifier.pmid25613112
dc.identifier.scopus2-s2.0-84925235845
dc.identifier.scopusqualityQ1
dc.identifier.startpage195
dc.identifier.urihttps://doi.org/10.1159/000369560
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21068
dc.identifier.volume89
dc.identifier.wosWOS:000351355200006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofRespiration
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectObstructive sleep apnea syndrome
dc.subjectApolipoprotein E
dc.subjectGene polymorphism
dc.titleThe Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants
dc.typeArticle

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