Thoroughbred mare's milk exhibits a unique and diverse free oligosaccharide profile

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dc.authoridSalcedo Dominguez, Jaime/0009-0005-4194-0239
dc.authoridFrese, Steven/0000-0003-2053-5830
dc.authoridbarile, daniela/0000-0002-3889-1596
dc.authoridKARAV, SERCAN/0000-0003-4056-1673
dc.contributor.authorKarav, Sercan
dc.contributor.authorSalcedo, Jaime
dc.contributor.authorFrese, Steven A.
dc.contributor.authorBarile, Daniela
dc.date.accessioned2025-01-27T20:50:11Z
dc.date.available2025-01-27T20:50:11Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe Thoroughbred is among the most valuable horse breeds, and its husbandry is a major industry. Mare's milk plays a major role in the health of neonatal foals. Although the main components of mare's milk are broadly characterized, free oligosaccharides (OS), which possess various bioactivities in many mammalian milks, have not been fully profiled in Thoroughbreds. The aim of this study was to identify and quantify OS in Thoroughbred mare's milk during the first week of lactation, when foals typically consume mare's milk exclusively. A total of 48 OS structures (including isomers and anomers), corresponding to 20 unique compositions, were identified by nano LC-Chip QToF-MS and confirmed by tandem mass spectrometry. Neutral OS were the most abundant glycans (58.3%), followed by acidic OS containing Neu5Ac (33.3%), a minor presence of fucosylated OS structures (6.25%) and one structure containing NeuGc (2.1%). Comparison with other well-characterized mammalian milks revealed that mare's milk shared 8 OS structures with human, bovine, pig and goat milk (i.e., 2 sialyllactose isomers, 3 hexose, LNH, LNT, and OS with the composition 3 Hex-1 Neu5Ac). Additionally, there were seven unique OS not previously found in other mammal milks. During the first 7 days of lactation, the percentage of neutral and fucosylated OS increased, whereas acidic OS decreased and the total OS concentration ranged from 217.8 mg.L-1 to 79.8 mg.L-1.
dc.identifier.doi10.1002/2211-5463.12460
dc.identifier.endpage1229
dc.identifier.issn2211-5463
dc.identifier.issue8
dc.identifier.pmid30087828
dc.identifier.scopus2-s2.0-85050408129
dc.identifier.scopusqualityQ2
dc.identifier.startpage1219
dc.identifier.urihttps://doi.org/10.1002/2211-5463.12460
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25434
dc.identifier.volume8
dc.identifier.wosWOS:000445645300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFebs Open Bio
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectfree oligosaccharides
dc.subjectMare's milk
dc.subjectnano LC-Chip QToF-MS
dc.titleThoroughbred mare's milk exhibits a unique and diverse free oligosaccharide profile
dc.typeArticle

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