Effect of percutaneous nephrolithotomy on renal functions in children: assessment by quantitative SPECT of 99mTc-DMSA uptake by the kidneys

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dc.contributor.authorCicekbilek, Izzet
dc.contributor.authorResorlu, Berkan
dc.contributor.authorOguz, Ural
dc.contributor.authorKara, Cengiz
dc.contributor.authorUnsal, Ali
dc.date.accessioned2025-01-27T20:58:00Z
dc.date.available2025-01-27T20:58:00Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To determine the impact of percutaneous nephrolithotomy (PNL) on global and regional renal function in children. Methods: In total, 40 children (41 renal units) undergoing PNL were included in this prospective study. All patients were evaluated using quantitative single-photon emission computed tomography (QSPECT) with technetium-99 m-dimercaptosuccinic acid (Tc-99m-DMSA) examinations before and 3 months after surgery. Results: The mean age was 9.5 years (range, 3-16), and the mean stone size was 3.4 cm (range, 2-6.5). Of the cases, 39 (95%) were managed as being stone-free after a single session of PNL. After additional treatment procedures, 40 (97.5%) of the cases were managed as being stone-free. Of the 41 renal units, new focal cortical defects on Tc-99m-DMSA scans were seen in 4 (9.7%) patients. Total relative uptake in the treated kidneys increased from 42.3% to 44.1%. The mean creatinine level before PNL was 1.18 +/- 0.45 (0.8-1.6) mg/dL compared with 1.16 (0.7-1.5) mg/dL by the end of the follow-up period (not statistically significantly different, p>0.05). Conclusions: PNL in children is a safe and feasible method for the maximal clearance of stones. QSPECT of Tc-99m-DMSA confirmed that renal function is preserved or even improved after percutaneous stone removal.
dc.identifier.doi10.3109/0886022X.2015.1056063
dc.identifier.endpage1121
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7
dc.identifier.pmid26067745
dc.identifier.scopus2-s2.0-84941888815
dc.identifier.scopusqualityQ2
dc.identifier.startpage1118
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1056063
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26578
dc.identifier.volume37
dc.identifier.wosWOS:000361339400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPercutaneous nephrolithotomy
dc.subjectrenal function
dc.subjectstone disease
dc.subjectrenal scintigraphy
dc.subjectrenal parenchymal scar
dc.titleEffect of percutaneous nephrolithotomy on renal functions in children: assessment by quantitative SPECT of 99mTc-DMSA uptake by the kidneys
dc.typeArticle

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