Impact of Nickel Oxide Nanoparticles (NiO) on Oxidative Stress Biomarkers and Hemocyte Counts of Mytilus galloprovincialis

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dc.authoridERTURK GURKAN, SELIN/0000-0003-3319-0616
dc.contributor.authorGurkan, Selin Erturk
dc.date.accessioned2025-01-27T20:14:20Z
dc.date.available2025-01-27T20:14:20Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, the toxic effects of nickel oxide nanoparticles (NiO-NPs) on the model organism Mediterranean mussel (Mytilus galloprovincialis) gill, digestive gland, and hemolymph tissues for 96 h were investigated. Lipid peroxidation (MDA) determination was performed to reveal the oxidative stress generation potential of nanoparticles, and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) enzyme levels were measured to determine antioxidant responses. Lysosomal membrane stability and total hemocyte counts were performed to determine cytotoxic effects. All parameters were altered in different concentrations of NiO-NPs (2, 20, and 200 mg L-1). The SOD levels increased depending on the concentration (p < 0.05), and the increases in CAT, GPx, and GST levels were lower at 20 mg L-1 concentration (p < 0.05). There was a slight difference between the exposure and the control groups in terms of GR enzyme. The MDA level increased in parallel with the concentration (p < 0.05), the stability of the cell membrane (p < 0.05), and the number of hemocyte cells decreased as a result of exposure (p < 0.05). The results emphasize that NiO-NPs may have negative effects on the aquatic environment.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Commission [FHD-2021-3601]
dc.description.sponsorshipThis study was funded by Canakkale Onsekiz Mart University Scientific Research Projects Commission (Project No: FHD-2021-3601).
dc.identifier.doi10.1007/s12011-022-03189-4
dc.identifier.endpage3441
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue7
dc.identifier.pmid35279797
dc.identifier.scopus2-s2.0-85126137351
dc.identifier.scopusqualityQ1
dc.identifier.startpage3429
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03189-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21051
dc.identifier.volume200
dc.identifier.wosWOS:000767908500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNickel oxide
dc.subjectOxidative stress
dc.subjectCytotoxicity
dc.subjectMediterranean mussel
dc.titleImpact of Nickel Oxide Nanoparticles (NiO) on Oxidative Stress Biomarkers and Hemocyte Counts of Mytilus galloprovincialis
dc.typeArticle

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