Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice

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dc.authoridRojas-Silva, Patricio/0000-0002-9611-3661
dc.authoridTumer, Tugba/0000-0002-1740-4867
dc.contributor.authorWaterman, Carrie
dc.contributor.authorRojas-Silva, Patricio
dc.contributor.authorTumer, Tugba Boyunegmez
dc.contributor.authorKuhn, Peter
dc.contributor.authorRichard, Allison J.
dc.contributor.authorWicks, Shawna
dc.contributor.authorStephens, Jacqueline M.
dc.date.accessioned2025-01-27T20:17:00Z
dc.date.available2025-01-27T20:17:00Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractScopeMoringa oleifera (moringa) is tropical plant traditionally used as an antidiabetic food. It produces structurally unique and chemically stable moringa isothiocyanates (MICs) that were evaluated for their therapeutic use in vivo. Methods and resultsC57BL/6L mice fed very high fat diet (VHFD) supplemented with 5% moringa concentrate (MC, delivering 66 mg/kg/d of MICs) accumulated fat mass, had improved glucose tolerance and insulin signaling, and did not develop fatty liver disease compared to VHFD-fed mice. MC-fed group also had reduced plasma insulin, leptin, resistin, cholesterol, IL-1, TNF, and lower hepatic glucose-6-phosphatase (G6P) expression. In hepatoma cells, MC and MICs at low micromolar concentrations inhibited gluconeogenesis and G6P expression. MICs and MC effects on lipolysis in vitro and on thermogenic and lipolytic genes in adipose tissue in vivo argued these are not likely primary targets for the anti-obesity and anti-diabetic effects observed. ConclusionData suggest that MICs are the main anti-obesity and anti-diabetic bioactives of MC, and that they exert their effects by inhibiting rate-limiting steps in liver gluconeogenesis resulting in direct or indirect increase in insulin signaling and sensitivity. These conclusions suggest that MC may be an effective dietary food for the prevention and treatment of obesity and type 2 diabetes.
dc.description.sponsorshipBotanical Research Center Pilot Program from the National Center for Complementary and Alternative Medicine (NCCAM) [5P50AT002776-08 S12-50318, P50AT002776-01]; Office of Dietary Supplements (ODS); NIH [T32:5T32AT004094-04, 1 U54 GM104940]; Ecuadorian government [SENESCYT-2011]
dc.description.sponsorshipThis study was supported by a Botanical Research Center Pilot Program Sub award 5P50AT002776-08 S12-50318 and P50AT002776-01 from the National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS). C.W. was also supported by NIH training Grant T32:5T32AT004094-04. C.W. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. P.R.S. was supported by a doctoral fellowship from Ecuadorian government SENESCYT-2011. Histology performed by Kenneth Reuhl is gratefully acknowledged. From Rutgers, we thank Julia Driefus for her technical support and Diana Cheng for discussions. From PBRC we thank Jennifer Rood, Youngmei Yu, Tamra Mendoza, Robbie Beyl (supported by NIH grant 1 U54 GM104940) and William Johnson for their technical support.
dc.identifier.doi10.1002/mnfr.201400679
dc.identifier.endpage1024
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.issue6
dc.identifier.pmid25620073
dc.identifier.scopus2-s2.0-84930179436
dc.identifier.scopusqualityQ1
dc.identifier.startpage1013
dc.identifier.urihttps://doi.org/10.1002/mnfr.201400679
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21459
dc.identifier.volume59
dc.identifier.wosWOS:000355745400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMolecular Nutrition & Food Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectDiabetes
dc.subjectInsulin resistance
dc.subjectIsothiocyanates
dc.subjectMoringa oleifera
dc.subjectObesity
dc.titleIsothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice
dc.typeArticle

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