High Inflammatory Activity Related to the Number of Metabolic Syndrome Components

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dc.authoridTURK, UGUR ONSEL/0000-0001-6348-6616
dc.authoridErcan, Ertugrul/0000-0003-0480-4738
dc.authoridAsgun, H. Fatih/0000-0002-8969-5886
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorAsgun, Fatih
dc.contributor.authorAlioglu, Emin
dc.contributor.authorErcan, Ertugrul
dc.contributor.authorTengiz, Istemihan
dc.contributor.authorTurk, Ugur
dc.contributor.authorSaygi, Serkan
dc.date.accessioned2025-01-27T20:23:14Z
dc.date.available2025-01-27T20:23:14Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIt has been known that each component of the metabolic syndrome (MS) has an atherogenic potential and increases the risk of cardiovascular events. Therefore, patients who have MS are candidates for the development of atherosclerosis and accompanying complications. In this study, the authors assessed the levels of acute phase reactants as an indicator of inflammation in patients with MS. Twenty-five patients with recently diagnosed MS and not treated before who had at least 3 of 5 diagnostic criteria of MS listed in the Third Report of the Adult Treatment Panel National Cholesterol Education Program (NCEP-ATP III) guidelines were included in the study. Twenty healthy patients constituted the control group. Inflammatory parameters were compared between the groups. There was no significant difference between the MS and control group with regard to age and sex. White blood cell count (/mm(3)), high-sensitivity C-reactive protein (hs-CRP), uric acid, interleukin (IL) 6, and fibrinogen levels were found to be significantly higher in the MS group. Number of MS components was strongly correlated with serum levels of hs-CRP (r=0.688, P=.0001), IL-6 (r=0.546, P=.0001), fibrinogen (r=0.551, P=.0001), uric acid (r=0.517, P=.0001), and leucocyte count (/mmr3) (r=0.456, P=.002). Inflammation plays an important role in atherosclerotic complications, which is activated in MS. Increased number of MS components are strongly associated with elevated inflammatory and metabolic markers. Measurement of serum inflammatory parameters in patients with MS may be beneficial in detection and management of cardiovascular events and in the assessment of efficacy of treatment. J Clin Hypertens (Greenwich). 2010;12:136-144. (C)2009 Wiley Periodicals, Inc.
dc.identifier.doi10.1111/j.1751-7176.2009.00229.x
dc.identifier.endpage144
dc.identifier.issn1524-6175
dc.identifier.issn1751-7176
dc.identifier.issue2
dc.identifier.pmid20167041
dc.identifier.scopus2-s2.0-75949124215
dc.identifier.scopusqualityQ1
dc.identifier.startpage136
dc.identifier.urihttps://doi.org/10.1111/j.1751-7176.2009.00229.x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22154
dc.identifier.volume12
dc.identifier.wosWOS:000273895000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Clinical Hypertension
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectC-Reactive Protein
dc.subjectLeft-Ventricular Hypertrophy
dc.subjectInsulin-Resistance
dc.subjectBlood-Pressure
dc.subjectBody-Size
dc.subjectHealth
dc.subjectAssociation
dc.subjectPlasma
dc.subjectAtherosclerosis
dc.subjectPopulation
dc.titleHigh Inflammatory Activity Related to the Number of Metabolic Syndrome Components
dc.typeArticle

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