In vitro evaluation of antimicrobial features of sugammadex

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dc.authoridYilmaz Hanci, Sevgi/0000-0002-1198-5277
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.contributor.authorHanci, Volkan
dc.contributor.authorVural, Ahmet
dc.contributor.authorHanci, Sevgi Yilmaz
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorOmur, Dilek
dc.contributor.authorUnver, Ahmet
dc.date.accessioned2025-01-27T21:00:00Z
dc.date.available2025-01-27T21:00:00Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Drugs administered by intravenous routes may be contaminated during several stages of production or preparation. Sugammadex is a modified gamma cyclodextrin. While research into the antibacterial effects of varieties of cyclodextrin is available, there are no studies focusing on the antibacterial effects of sugammadex. This study investigates the in vitro antimicrobial activity of sugammadex. Materials and methods: The in vitro antimicrobial activity of sugammadex was investigated using the broth microdilution method. The pH of the test solution was determined using a pH meter. The test microorganisms included Staphylococcus aureus ATCC 29213, Enterococcus fecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. In the second phase of the study 100 mg/mL sugammadex (54 mu g) was contaminated with test microorganisms (50 mu g), including S. aureus ATCC 29213, E. fecalis ATCC 29212, E. cob ATCC 25922 and P aeruginosa ATCC 27853, Left to incubate for 24 h and then the bacterial production in sugammadex was evaluated. Results: The pH of the test solutions ranged between 7.25 and 6.97. Using the microdilution method, sugammadex had no antibacterial effect on S. aureus, E. fecalis, E. coli and P aeruginosa at any concentration. In the second phase of the study bacterial production was observed after 24h in 100 mg/mL sugammadex contaminated with the test microorganisms S. aureus, E. fecalis, E. coli and P. aeruginosa. Conclusions: Sugammadex had no antimicrobial effect on the test microorganisms, S. aureus, E. fecal's, E. coli and P aeruginosa. Care should be taken that sterile conditions are maintained in the preparation of sugammadex; that the same sugammadex preparation not be used for more than one patient; and that storage conditions are adhered to after sugammadex is put into the injector. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights
dc.identifier.doi10.1016/j.bjane.2013.09.003
dc.identifier.endpage108
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue2
dc.identifier.pmid24794452
dc.identifier.scopus2-s2.0-84920481163
dc.identifier.scopusqualityN/A
dc.identifier.startpage105
dc.identifier.urihttps://doi.org/10.1016/j.bjane.2013.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26906
dc.identifier.volume64
dc.identifier.wosWOS:000337101400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofRevista Brasileira De Anestesiologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSugammadex
dc.subjectAntimicrobial effect
dc.subjectS. aureus
dc.subjectE. fecalis
dc.subjectE. coli
dc.subjectP. aeruginosa
dc.titleIn vitro evaluation of antimicrobial features of sugammadex
dc.title.alternativeAvaliação in vitro das características antimicrobianas de sugamadex
dc.typeArticle

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