Serum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism

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dc.authoridekinci, ferhat/0000-0002-9317-942X
dc.contributor.authorYasar, Hamiyet Yilmaz
dc.contributor.authorDemirpence, Mustafa
dc.contributor.authorColak, Ayfer
dc.contributor.authorYurdakul, Leman
dc.contributor.authorZeytinli, Merve
dc.contributor.authorTurkon, Hakan
dc.contributor.authorEkinci, Ferhat
dc.date.accessioned2025-01-27T20:22:56Z
dc.date.available2025-01-27T20:22:56Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: In this study, we aimed to evaluate serum irisin and apelin levels in patients with subclinical hypothyroidism (SCH) when they were subclinical hypothyroid and become euthyroid after levothyroxine therapy and association of these adipokines with markers of atherosclerosis such as serum homocysteine levels and carotid intima-media thickness (IMT). Subjects and methods: The study included 160 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto's thyroiditis and 86 euthyroid healty subjects. Serum glucose and lipid profile, insulin, HOMA, TSH, free T3, free T4, anti-thyroperoxidase and anti-thyroglobulin antibodies, homocysteine, apelin and irisin levels were measured in all study subjects. Thyroid and carotid ultrasound examinations were performed. The subclinical hypothyroid group was reevaluated after 12-weeks of levothyroxine therapy when they became euthyroid. Results: Clinical characteristics of the patient and control group were similar. Glucose, insulin and HOMA levels, lipid parameters and free T3 were similar between the two groups.. Serum homocystein was higher and apelin was lower in patients with SCH, but irisin levels were similar between the two groups. While thyroid volume was lower, carotid IMT was significantly greater in patients with SCH (pCarotidIMT: 0,01). After 12-weeks of levothyroxine therapy, all the studied parameters remained unchanged except, serum freeT4, TSH, homocystein and apelin. While homocystein decreased (p: 0,001), apelin increased significantly (p = 0,049). In multivariate analysis, low apelin levels significantly contributed to carotid IMT (p = 0,041). Conclusions: Apelin-APJ system may play a role in vascular and cardiac dysfunction in patients with SCH and treatment of this condition may improve the risk of cardiovascular disease.
dc.identifier.doi10.20945/2359-3997000000106
dc.identifier.endpage21
dc.identifier.issn2359-3997
dc.identifier.issn2359-4292
dc.identifier.issue1
dc.identifier.pmid30864627
dc.identifier.scopus2-s2.0-85062866791
dc.identifier.scopusqualityQ3
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.20945/2359-3997000000106
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22074
dc.identifier.volume63
dc.identifier.wosWOS:000460761200005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArchives of Endocrinology Metabolism
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSubcinical hypothyroidism
dc.subjectirisin, apelin
dc.subjectatherosclerosis
dc.subjectcarotid intima-media thickness
dc.titleSerum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism
dc.typeArticle

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