Synthesis of new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives as carbonic anhydrase inhibitors

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dc.authoridErgun, Adem/0000-0003-4647-6058
dc.authoridGencer, Nahit/0000-0001-7092-8857
dc.authoridARSLAN, Mustafa/0000-0003-0796-4374
dc.authoridBerber, Nurcan/0000-0002-1595-585X
dc.contributor.authorBerber, Nurcan
dc.contributor.authorArslan, Mustafa
dc.contributor.authorVural, Firat
dc.contributor.authorErgun, Adem
dc.contributor.authorGencer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2025-01-27T21:01:47Z
dc.date.available2025-01-27T21:01:47Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHuman carbonic anhydrase I and II isoenzymes (hCA I and II) are important metabolic enzymes. In this study, a new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives were synthesized and also some inhibition parameters including IC50(hydratese) and inhibition constant values (K-i, esterase) were determined. All studied compounds exhibited potent inhibition against these enzymes. They inhibited carbonic anhydrases (CAs) with the IC(50)values of 113 to 395.8 nM (K-i = 77.38-319.59 nM) for hCA I and 91.9 to 516 nM (K-i = 62.79-425.89 nM) for hCA II. Among the compounds,5cwas found to be the most active one (K-i: 77.38 nM) for hCA I and5gwas found for hCA II with the value of 62.79 nM.
dc.description.sponsorshipResearch Fund of the Balikesir universitesi Scientific Research Projects Unit (TURKEY) [2017/166]
dc.description.sponsorshipThis study was supported by the Research Fund of the Balikesir universitesi Scientific Research Projects Unit (TURKEY) (2017/166).
dc.identifier.doi10.1002/jbt.22596
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue12
dc.identifier.pmid32762006
dc.identifier.scopus2-s2.0-85089026922
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22596
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27189
dc.identifier.volume34
dc.identifier.wosWOS:000556034700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subject2-iminothiazoline
dc.subjectcarbonic anhydrase
dc.subjectenzyme inhibitor
dc.subjectsulfonamide
dc.titleSynthesis of new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives as carbonic anhydrase inhibitors
dc.typeArticle

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