Efficiency of Choroidal Thickness Monitoring to Prevent Topiramate Induced Acute Angle Closure Glaucoma

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dc.contributor.authorKara, Selcuk
dc.contributor.authorOzcimen, Muammer
dc.contributor.authorAydin, Hacer Doganay
dc.contributor.authorSakarya, Yasar
dc.contributor.authorGencer, Baran
dc.contributor.authorTufan, H. Ali
dc.contributor.authorArikan, Sedat
dc.date.accessioned2025-01-27T20:26:57Z
dc.date.available2025-01-27T20:26:57Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study is to investigate early findings of the choroidal effusion induced by topiramate use which is thought to be responsible for bilateral acute angle closure glaucoma. Enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) recordings of 34 patients who has been used topiramate for the prophylaxis of migraines, before and after 2 weeks of drug use were retrospectively investigated. Alterations in subfoveal choroidal layer thicknesses and peripapillary retinal nerve fiber layer (RNFL) thickness were measured manually by two masked observers. The mean measurements of subfoveal choroidal layer thickness were 315.67 +/- 80.98 mu m before use of the drug and 314.89 +/- 76.40 mu m in 2nd week of drug use. However, this slight decrease was not statistically significant. The mean peripapillary RNFL thickness was 104.47 +/- 10.48 mu m before use of the drug, and significant thinning was found only in the temporal quadrant during follow-up after use of the drug (p=0.008). No subclinical subfoveal choroidal effusions were encountered using EDI SD-OCT in patients after 2 weeks of topiramate use. Further studies are needed to find out the cause of bilateral ciliochoroidal effusion related with topiramate use.
dc.identifier.doi10.15197/sabad.1.12.02
dc.identifier.endpage12
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84961313197
dc.identifier.scopusqualityN/A
dc.identifier.startpage7
dc.identifier.urihttps://doi.org/10.15197/sabad.1.12.02
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22518
dc.identifier.volume12
dc.identifier.wosWOS:000367540700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectChoroidal effusion
dc.subjecttopiramate
dc.subjectacute angle closure glaucoma
dc.subjectoptical coherence tomography
dc.titleEfficiency of Choroidal Thickness Monitoring to Prevent Topiramate Induced Acute Angle Closure Glaucoma
dc.title.alternativeTopiramata bağlı akut açı kapanması glokomunu önlemede koroidal kalınlık izleminin etkinliği
dc.typeArticle

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