Assessment of ADAM17 and ADAM10 proteins with CXCL10 and thyroid autoimmunity in vitiligo pathogenesis

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dc.contributor.authorKilic, Sevilay
dc.contributor.authorSehitoglu, Hilal
dc.contributor.authorGul, Ceren
dc.date.accessioned2025-01-27T20:29:35Z
dc.date.available2025-01-27T20:29:35Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description4th Ulusal Psoriasis Symposium -- 2020 -- ELECTR NETWORK
dc.description.abstractIntroduction: Vitiligo is an acquired chronic pigmentation disorder. The etiopathogenesis is still not fully understood. Aim: To research the correlation of ADAM proteins, shown to be associated with autoimmune diseases like rheumatoid arthritis and lupus erythematosus, with vitiligo also considered to be an autoimmune disease. Material and methods: The study included a patient group of 45 patients with the diagnosis of vitiligo and a control group of 45 healthy adults. The ADAM10 and ADAM17 protein serum levels and CXCL10 and thyroid autoantibody anti-TG and anti-TPO levels along with FT3, FT4, and TSH hormone levels were determined with the ELISA method. Statistical analysis of results was made with the SPSS 22.0 program. Results: In vitiligo patients, the ADAM10 levels (2.34 +/- 0.80 pg/ml) were statistically significantly low compared to the control group (10.29 +/- 1.71 pg/ml) (p < 0.05), while the ADAM17 levels (128.51 +/- 14.37 pg/ml) were statistically significantly high compared to the control group (16.30 +/- 6.31 pg/ml) (p < 0.05). Additionally, the CXCL10 levels were observed to be statistically significantly higher in the patient group (275.11 +/- 62.36) than in the control group (107.08 +/- 33.12). Thyroid autoimmunity test results (anti-TG, anti-TPO, and TSH) were shown to be different to a statistically significant degree in the patient group compared to the control group (p < 0.001, p < 0.000, p = 0.003, respectively). Statistical analyses used the Kolmogorov-Smirnov, Mann-Whitney U test, and the independent T-test. Conclusions: We obtained data that are important in terms of understanding the pathogenesis. ADAM10 and ADAM17 proteins may be new targets for future therapeutic approaches.
dc.description.sponsorshipCanakkale Onsekiz Mart University; Canakkale Onsekiz Mart University Scientific Research Coordination Unit [TTU-2018-2677]
dc.description.sponsorshipThis research was supported by funds from the Canakkale Onsekiz Mart University. This project has been funded in whole with the Canakkale Onsekiz Mart University Scientific Research Coordination Unit, Project number: TTU-2018-2677.
dc.identifier.doi10.5114/ada.2022.115891
dc.identifier.endpage400
dc.identifier.issn1642-395X
dc.identifier.issn2299-0046
dc.identifier.issue2
dc.identifier.pmid35645671
dc.identifier.scopus2-s2.0-85130876899
dc.identifier.scopusqualityQ2
dc.identifier.startpage397
dc.identifier.urihttps://doi.org/10.5114/ada.2022.115891
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22989
dc.identifier.volume39
dc.identifier.wosWOS:000798157800024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectvitiligo
dc.subjectADAM10
dc.subjectADAM17
dc.subjectCXCL10
dc.subjectthyroid autoimmunity
dc.titleAssessment of ADAM17 and ADAM10 proteins with CXCL10 and thyroid autoimmunity in vitiligo pathogenesis
dc.typeConference Object

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