Alterations in Iris Structure and Pupil Size Related to Alpha-1 Adrenergic Receptor Antagonists Use: Implications for Floppy Iris Syndrome

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dc.authoridAlan, Cabir/0000-0002-6024-4475
dc.authoridKURT, HASAN ANIL/0000-0001-7292-2248
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorGencer, Baran
dc.contributor.authorKara, Selcuk
dc.contributor.authorComez, Arzu Taskiran
dc.contributor.authorKurt, Hasan Anil
dc.contributor.authorAlan, Cabir
dc.date.accessioned2025-01-27T20:20:13Z
dc.date.available2025-01-27T20:20:13Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To evaluate structural alterations of iris and pupil diameters (PDs) in patients using systemic alpha-1-adrenergic receptor antagonists (alpha-1ARAs), which are associated with intraoperative floppy iris syndrome (IFIS). Methods: Eighty-eight eyes of 49 male were evaluated prospectively. Patients were assigned to 2 different groups. Study group included 23 patients taking any systemic alpha-1ARAs treatment, and control group included 26 patients not taking any systemic alpha-1ARAs treatment. All patients underwent anterior segment optical coherence tomography to evaluate iris thickness at the dilator muscle region (DMR) and at the sphincter muscle region (SMR). The PD was measured using a computerized infrared pupillometer under scotopic and photopic illumination. Results: The study group included 46 eyes of 23 patients and the control group included 42 eyes of 26 patients. Most treated patients were on tamsulosin (16/23). Mean age was similar in the study and control groups (61.9 +/- 7.1 vs. 60.3 +/- 8, 2 years, nonsignificant). DMR (506.5 +/- 89.4 vs. 503.6 +/- 83.5 mu m), SMR (507.8 +/- 78.1 vs. 522.1 +/- 96.4 mu m) and the DMR/SMR ratio (1.0 +/- 0.15 vs. 0.99 +/- 0.23 mm) was similar in the study and control groups and these differences were nonsignificant. Scotopic PDs were also similar in both groups (3.99 +/- 1.11 vs. 3.74 +/- 1.35, nonsignificant). A significantly reduced photopic PD (2.89 +/- 0.55 vs. 3.62 +/- 0.64, P < 0.001) and an increased scotopic/photopic PD (1.42 +/- 0.44 vs. 1.02 +/- 0.30, P < 0.001) were found in the study group. Conclusions: Evaluating PD alterations might be more useful than evaluating iris structural alterations in predicting IFIS. There is still a need for a reliable method that will determine the possibility of IFIS.
dc.identifier.doi10.1089/jop.2012.0151
dc.identifier.endpage413
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue4
dc.identifier.pmid23215540
dc.identifier.scopus2-s2.0-84880532341
dc.identifier.scopusqualityQ1
dc.identifier.startpage410
dc.identifier.urihttps://doi.org/10.1089/jop.2012.0151
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21619
dc.identifier.volume29
dc.identifier.wosWOS:000318221900008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofJournal of Ocular Pharmacology and Therapeutics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCataract-Surgery
dc.subjectSaw Palmetto
dc.subjectTamsulosin
dc.subjectBlockers
dc.titleAlterations in Iris Structure and Pupil Size Related to Alpha-1 Adrenergic Receptor Antagonists Use: Implications for Floppy Iris Syndrome
dc.typeArticle

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