Serum cortisol levels following acute experimental spinal cord injury

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dc.contributor.authorGezici, Ali Riza
dc.contributor.authorKarakas, Alper
dc.contributor.authorErgun, Ruchan
dc.contributor.authorGunduz, Bulent
dc.date.accessioned2025-01-27T20:44:14Z
dc.date.available2025-01-27T20:44:14Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and purpose: Cortisol has neuroprotective effects. We monitored the serum cortisol levels after cervical and thoracic spinal cord injury (SCI) in four groups of rats. Materials and methods: Forty male Sprague-Dawley rats were randomized to four groups. The control group received neither laminectomy nor SCI. The sham group received laminectomy without SCT. The cervical spinal trauma group received a C5-C6 laminectomy and spinal trauma at this level. The thoracic spinal trauma group received a T6-T7 laminectomy and spinal trauma. Blood samples were drawn 2, 6, 12 and 24 hours after surgeries and assayed immediately. Results: The level of cortisol in the cervical spinal trauma group was highest at the second hour of the experiment and the lowest in control and sham-operated groups at the same time. At the sixth hour, cortisol levels increased in control and sham operated groups decreased, but increased in thoracic and cervical groups decreased, but increased in thoracic and cervical groups. After the 24(th) hour, serum cortisol levels in thoracic and cervical groups decreased but did not change significantly in control and sham-operated animals. Conclusion: Activation of endogen cortisol secretion of the organism starts immediately after the SCI injury and throughout the experiment the serum cortisol levels in neurotrauma groups remained high compared with the control and sham-operated groups. At the beginning, the level of neurological lesion (cervical or thoracic) affected differently the level of serum cortisol at a statistically significant level but this difference disappeared at the 6(th) hour.
dc.identifier.endpage357
dc.identifier.issn0028-3843
dc.identifier.issn1897-4260
dc.identifier.issue4
dc.identifier.pmid19742394
dc.identifier.scopus2-s2.0-70449719189
dc.identifier.scopusqualityQ1
dc.identifier.startpage352
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24513
dc.identifier.volume43
dc.identifier.wosWOS:000271451600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofNeurologia I Neurochirurgia Polska
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcortisol
dc.subjectneuroprotection
dc.subjectspinal cord injury
dc.subjectELISA
dc.titleSerum cortisol levels following acute experimental spinal cord injury
dc.typeArticle

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