Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats

Basit Öğe Kaydı
dc.authoridOvali, Mehmet Akif/0000-0002-3672-871X
dc.authoridCOSKUN, OZLEM/0000-0002-0741-5001
dc.authoridTurkon, Hakan/0000-0003-1888-9322
dc.authoriduzun, metehan/0000-0003-1406-5473
dc.authoridOztopuz, Ozlem/0000-0002-1373-6311
dc.contributor.authorOztopuz, Ozlem
dc.contributor.authorTurkon, Hakan
dc.contributor.authorBuyuk, Basak
dc.contributor.authorCoskun, Ozlem
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:34:35Z
dc.date.available2025-01-27T20:34:35Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractValproic acid (VPA) is a anticonvulsant and mood-stabilizing agent used to treat epilepsy in patients of all ages. However, it can cause hepatotoxicity with increased oxidative stress. Melatonin (MEL) is known as antioxidant and antiinflammatory agent. Therefore, the present study designed to investigate the probable protective role of melatonin against VPA-induced liver toxicity. For that purpose, 28 Wistar rats were randomly selected and divided into four groups, namely the Group C (vehicle), VPA (500 mg/kg/day VPA), MEL + VPA (10 mg/kg/day melatonin + 500 mg/kg/day VPA) and MEL (10 mg/kg/day melatonin). The agents were given by oral gavage for 14 days. Blood and liver tissue samples from all the rats were harvested on the 15th day of experiment. Biochemical analyses were conducted on the blood samples. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), alpha glutathione S-transferases (alpha-GST), nuclear factor-kappa B (NF-kappa B), myeloperoxidase (MPO) and changes in gene expression were examined in the liver tissues. Also, liver histopathological analyses were conducted. VPA administration significantly increased the levels of alpha-GST, MDA, NF-kappa B and of IL-1 beta, TNF-alpha gene expression in the liver compared to Group C. Moreover, vacuolization, hydropic degeneration, inflammatory cell infiltration, and sinusoidal congestion were commonly detected in the VPA-treated group along with the highest apoptotic index (TUNEL staining) values. Melatonin administration was revealed to exhibit powerful protective properties at cellular, inflammatory and oxidative level activities against VPA-induced liver toxicity. Therefore, melatonin administration may be used as an adjuvant therapy against to VPA-induced liver toxicity.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects [TSA-2017-1108]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University Scientific Research Projects with project number TSA-2017-1108.
dc.identifier.doi10.1007/s11033-019-05134-6
dc.identifier.endpage325
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1
dc.identifier.pmid31624995
dc.identifier.scopus2-s2.0-85074012215
dc.identifier.scopusqualityQ2
dc.identifier.startpage317
dc.identifier.urihttps://doi.org/10.1007/s11033-019-05134-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23363
dc.identifier.volume47
dc.identifier.wosWOS:000490825200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSodium valproate
dc.subjectMelatonin
dc.subjectHepatotoxicity
dc.titleMelatonin ameliorates sodium valproate-induced hepatotoxicity in rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu