Gold and silver nanoparticle decorated biocompatible and antibacterial xanthan gum/poly (HEMA-co-APTMACl) hydrogels for wound healing

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dc.authorid0000-0001-6589-9844
dc.contributor.authorKulabas, Seda Savranoglu
dc.contributor.authorAtli, Ilknur
dc.contributor.authorAtalay, Hazal Nazlican
dc.contributor.authorTumer, Tugba Boyunegmez
dc.contributor.authorOzay, Hava
dc.contributor.authorOzay, Ozgur
dc.date.accessioned2026-02-03T12:02:50Z
dc.date.available2026-02-03T12:02:50Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA delayed skin wound healing process increases the risk of infection and necessitates implementing effective treatment strategies. From this perspective, biocompatible and antibacterial hydrogels stand out as innovative biomaterials that support wound healing. In this research, a semi-interpenetrating polymer network (s-IPN) strategy was used to improve the mechanical strength, cytocompatibility, and antibacterial properties of natural polysaccharide-based hydrogels. In this context, natural polymer-based XG/poly (HEMA-co-APTMACl) hydrogels were synthesized by redox polymerization reaction. The stability of metal nanoparticles was ensured by utilizing the rich polyphenol and flavonoid components of C. Orientalis. The synthesized hydrogels were in situ functionalized with biosynthesized silver (55 nm) and gold (56 nm) nanoparticles to enhance their biocompatibility and biofunctionality. Their antibacterial activity was assessed against P. aeruginosa, S. aureus, B. cereus, and E. faecalis using the disk diffusion method. Hydrogelfilm@Ag inhibited all tested bacterial strains (7.5-8.8 mm), while Hydrogelfilm@Au exhibited stronger antibacterial activity, particularly against E. faecalis (10.3 mm) and B. cereus (9.7 mm). In contrast, the Hydrogelfilm was only effective against S. aureus (7.7 mm). The hydrogel formulations were tested for cytocompatibility and wound healing potential using HUVECs. All hydrogels composites (Hydrogelfilm@Au, @Ag, and @HF) were non-toxic and exhibited enhanced biocompatibility, promoting significant cell proliferation at all tested concentrations (5-20%). In wound healing assays, Hydrogelfilm@HF achieved complete wound closure within 12 h even at a 5% concentration, demonstrating superior regenerative potential. Overall, hydrogels incorporating green-synthesized silver and gold nanoparticles demonstrated excellent antibacterial and wound-healing properties, highlighting their promise as advanced biomaterials for tissue regeneration applications.
dc.identifier.doi10.1007/s42247-025-01225-2
dc.identifier.issn2522-5731
dc.identifier.issn2522-574X
dc.identifier.scopus2-s2.0-105016753056
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s42247-025-01225-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34886
dc.identifier.wosWOS:001574642600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofEmergent Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectHydrogel
dc.subjectBiocompatible composite
dc.subjectGreen nanoparticle
dc.subjectAntibacterial film
dc.subjectCytocompatibility
dc.titleGold and silver nanoparticle decorated biocompatible and antibacterial xanthan gum/poly (HEMA-co-APTMACl) hydrogels for wound healing
dc.typeArticle

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