Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C>T Gene Polymorphism in Differentiated Thyroid Cancers

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dc.contributor.authorOzdemir, Semra
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorSılan, Fatma
dc.contributor.authorAtik, Sinem Yalcintepe
dc.contributor.authorTurgut, Bulent
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:45:54Z
dc.date.available2025-01-27T20:45:54Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC). Materials and Methods: In the current case-control study, 60 differentiated thyroid cancers (DTC)- 45 papillary TC (PTC), 9 follicular TC(FTC) and 6 well-differentiated tumors of uncertain malignant potential (WDT-UMP) were examined. Results were compared to a healthy control group (n=58) from the same population. Genomic DNA was extracted from peripheral blood with EDTA and the target gene was genotyped by real-time PCR. Results: Carriers of the variant allele of MDR1 exon 26 polymorphism were at 2.8-fold higher risk of DTC than the control group (odds ratio [OR]: 0.3805, 95% confidence interval [Cl]: 0.1597-0.9065 (p>0.046). Conclusions: Presented results suggest that the MDR1 3435TT genotype might influence risk of development of DTC and that the CC genotype might be linked to a poor prognosis. Large-scale studies are now needed to validate this association.
dc.identifier.doi10.7314/APJCP.2013.14.5.3213
dc.identifier.endpage3217
dc.identifier.issn1513-7368
dc.identifier.issue5
dc.identifier.pmid23803106
dc.identifier.scopus2-s2.0-84880348929
dc.identifier.scopusqualityQ3
dc.identifier.startpage3213
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.5.3213
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24757
dc.identifier.volume14
dc.identifier.wosWOS:000331473400091
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectDifferentiated thyroid carcinoma
dc.subjectMDR1 gene
dc.subjectincreased T allele frequency in codon C3435T
dc.titlePossible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C>T Gene Polymorphism in Differentiated Thyroid Cancers
dc.typeArticle

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