The effects of branched chain amino acid supplement on kidney tissue of exercising rats

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dc.authoridEROGLU, Huseyin Avni/0000-0002-1040-3255
dc.authoridAYDEGER, Cemre/0000-0003-1654-6406
dc.contributor.authorAydeger, Cemre
dc.contributor.authorEroglu, Huseyin Avni
dc.date.accessioned2025-01-27T20:45:45Z
dc.date.available2025-01-27T20:45:45Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: One of the supplements used in exercise programs are branched-chain amino acids (BCAAs), which are preferred because of their effect on the regeneration of muscle protein synthesis. However, due to their properties, BCAAs increase their amount in the blood in a short time. In this case the result may increase the workload of the kidneys. Based on the information, this study investigated the effects of resistance exercise and BCAA supplements on kidney tissue. Methods: A total of 24 Wistar Albino male rats were equally divided into 4 groups: Control, BCAA, Exercise and Exercise + BCAA. In the six-week study, resistance swimming exercise was applied to the exercise groups. BCAA supplementation was given to BCAA groups at 2.5 mg/kg doses before exercise. At the end of the study, histological, immunochemical and RT-PCR analyzes were performed. Results: As a result of the findings, it was found that the use of BCAA supplements together with exercise caused tubular necrosis (p=0.002). There was a significant increase in caspase 3 IHC staining findings in BCAA and Exercise + BCAA groups compared to the control group (p=0.011; p=0.02). In addition, KIM-1 expression levels were higher in the Exercise group than in all other groups (p=0.004; p = 0.003; p=0.008). Conclusion: As a result, BCAA consumption with resistance exercise caused damage to kidney tissue.
dc.description.sponsorshipCanakkale Onsekiz Mart University the Scientific Research Coordination Unit [TYL-2019-3141]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University the Scientific Research Coordination Unit, Project number: TYL-2019-3141.
dc.identifier.endpage133
dc.identifier.issn0326-3428
dc.identifier.issn2346-8548
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85132813778
dc.identifier.scopusqualityQ4
dc.identifier.startpage124
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24706
dc.identifier.volume42
dc.identifier.wosWOS:000823265700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsoc Regional Dialisis Trasplantes Renales
dc.relation.ispartofRevista De Nefrologia Dialisis Y Trasplante
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectresistance exercise
dc.subjectkidney damage
dc.subjectcaspase 3
dc.subjectbranched chain amino acids
dc.subjectKIM-1
dc.titleThe effects of branched chain amino acid supplement on kidney tissue of exercising rats
dc.title.alternativeLos efectos del suplemento de aminoácidos de cadena ramificaden el tejido renal de ratas en ejercicio
dc.typeArticle

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