Prophylactic effect of N-acetylcysteine against sodium fluoride-induced blood oxidative stress in mice

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dc.authoridInce, Sinan/0000-0002-1915-9797
dc.authoridALTINTAS, Levent/0000-0002-5148-723X
dc.authoridEssiz, Dinc/0000-0002-4759-7858
dc.contributor.authorAltintas, Levent
dc.contributor.authorEssiz, Dinc
dc.contributor.authorEraslan, Gokhan
dc.contributor.authorInce, Sinan
dc.contributor.authorArslanbas, Emre
dc.date.accessioned2025-01-27T20:43:35Z
dc.date.available2025-01-27T20:43:35Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNinety female Balb/c mice were used. The animals were allocated to evenly six groups. While the first group was maintained as control. Groups 3, 4, 5, and 6 were administered 750 ppm, 1500 ppm, 3000 ppm, and 6000 ppm of N-acetylcysteine, respectively, for a period of 15 days. After day 15. Groups 2-6 were administered sodium fluoride, containing 100 ppm fluoride in drinking water, for another 15 days. Plasma malondialdehyde (MDA) levels and erythrocyte superoksid dismutase (SOD) and catalase (CAT) activities were determined at the beginning of the trial and on days 15 and 30. According to the data obtained in the present study, N-acetylcysteine, when administered at the indicated doses, did not produce a significant alteration in any of the three parameters investigated. On the other hand, while the plasma MDA level was determined to have increased significantly, erythrocyte SOD and CAT activities were ascertained to have decreased significantly in the group, which was administered sodium fluoride alone on day 30. In the groups, which were administered N-acetylcysteine prior to sodium fluoride, however, it was observed that, after sodium fluoride administration, plasma MDA levels and erythrocyte SOD and CAT activities drew closer to the values of the control group. (C) 2010 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.fct.2010.07.015
dc.identifier.endpage2841
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue10
dc.identifier.pmid20637250
dc.identifier.scopus2-s2.0-77956342349
dc.identifier.scopusqualityQ1
dc.identifier.startpage2838
dc.identifier.urihttps://doi.org/10.1016/j.fct.2010.07.015
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24276
dc.identifier.volume48
dc.identifier.wosWOS:000282543000042
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectN-acetylcysteine
dc.subjectSodium fluoride
dc.subjectOxidative stress
dc.subjectMice
dc.titleProphylactic effect of N-acetylcysteine against sodium fluoride-induced blood oxidative stress in mice
dc.typeArticle

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