Predictive value of elevated neutrophil-lymphocyte ratio for left ventricular systolic dysfunction in patients with non ST-elevated acute coronary syndrome

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dc.contributor.authorBekler, Adem
dc.contributor.authorErbag, Gokhan
dc.contributor.authorSen, Hacer
dc.contributor.authorGazi, Emine
dc.contributor.authorOzcan, Sedat
dc.date.accessioned2025-01-27T20:11:53Z
dc.date.available2025-01-27T20:11:53Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: We aimed to study the predictive value of the neutrophil-lymphocyte ratio (NLR) for left ventricular systolic dysfunction (LVSD) in patients with non ST-elevated acute coronary syndrome (NST-ACS). Methods: A total of 405 patients (mean age 62 years and 75% male) with NST-ACS were included in the study. The study population was divided into tertiles based on admission NLR values. The low, medium and high tertiles defined as NLR <= 1.81 (n=135), 1.81<=.3.2 (n=135) and NLR>3.2 (n=135), respectively. Results: The patients in the high NLR group were older (p<0.001), have higher rate of diabetes mellitus (p=0.028) and non-ST elevated myocardial infarction (NSTEMI) (p<0.001) and have lower left ventricular ejection fraction (LVEF) (p<0.001). Baseline WBC (p=0.02) and neutrophil (p<0.001) levels and NLR (p<0.001) were significantly higher, baseline hemoglobin (p=0.044), hematocrit (p=0.019) and lymphocyte (p<0.001) levels were significantly lower in the high NLR group. NLR was negatively correlated with LVEF in correlation analysis. An NLR >3.2 and age >= 70 were found to be an independent predictor of systolic dysfunction in multivariate analyses. Conclusion: An NLR >3.2 is a useful predictor for LVSD in patients with NST-ACS. The practice of using an NLR count on admission may be useful for identifying high-risk patients and their associated treatment methods.
dc.identifier.doi10.12669/pjms.311.5967
dc.identifier.endpage163
dc.identifier.issn1682-024X
dc.identifier.issue1
dc.identifier.pmid25878635
dc.identifier.scopus2-s2.0-84919808054
dc.identifier.scopusqualityQ1
dc.identifier.startpage159
dc.identifier.urihttps://doi.org/10.12669/pjms.311.5967
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20764
dc.identifier.volume31
dc.identifier.wosWOS:000349936500032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherProfessional Medical Publications
dc.relation.ispartofPakistan Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute coronary syndrome
dc.subjectEjection fraction
dc.subjectMyocardial infarction
dc.subjectNeutrophil-lymphocyte ratio
dc.subjectSystolic dysfunction
dc.titlePredictive value of elevated neutrophil-lymphocyte ratio for left ventricular systolic dysfunction in patients with non ST-elevated acute coronary syndrome
dc.typeArticle

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