Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality

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dc.authoridTunalı, Mustafa / 0000-0002-1251-3431
dc.authoridErcan, Esra / 0000-0002-8696-4198
dc.authoridGüven Bağla, Aysel / 0000-0002-1501-9324
dc.authoridAytürk, Nilüfer / 0000-0003-0344-6246
dc.authoridSıddıkoğlu, Duygu / 0000-0002-5093-7948
dc.authoridBilgin, Vildan / 0000-0002-0937-6763
dc.contributor.authorTunalı, Mustafa
dc.contributor.authorErcan, Esra
dc.contributor.authorPat, Suat
dc.contributor.authorSarıca, Emrah
dc.contributor.authorGüven Bağla, Aysel
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorSıddıkoğlu, Duygu
dc.contributor.authorBilgin, Vildan
dc.date.accessioned2025-01-27T20:39:22Z
dc.date.available2025-01-27T20:39:22Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium's superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface's debut in our PRF production endeavors. Employing a rapid thermionic vacuum arc (TVA) process under high vacuum, we conducted comprehensive analyses of the tubes. Comprehensive analyses, including X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), were conducted on the nano-titanium-coated glass tubes. Three PRF types were formulated: silica-activated leukocyte- and platelet-rich fibrin (L-PRF, control group), machined-surface titanium tubes (T-PRF), and nano-titanium-coated tubes (nanoT-PRF). Analyses unveiled denser fibrin areas in nanoT-PRF than T-PRF, with the least dense areas in L-PRF. Cell distribution paralled between nanoT-PRF and T-PRF groups, while L-PRF cells were embedded in the fibrin border. NanoT-PRF exhibited the densest autogenous fibrin structure, suggesting prolonged in vivo resorption. Additionally, we explore the potential practicality of single-use production for nanoT-PRF tubes, introducing a promising clinical advancement. This study marks a significant stride in innovative biomaterial design, contributing to the progress of regenerative medicine.
dc.description.sponsorshipanakkale Onsekiz Mart niversitesi
dc.description.sponsorshipThe authors thank the pregraduate students of Canakkale Onsekiz Mart University, Dentistry Faculty and Dr. Raif Alan for their enthusiastic support.
dc.identifier.doi10.1007/s10856-024-06838-3
dc.identifier.issn0957-4530
dc.identifier.issn1573-4838
dc.identifier.issue1
dc.identifier.pmid39503916
dc.identifier.scopus2-s2.0-85208602786
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10856-024-06838-3
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23931
dc.identifier.volume35
dc.identifier.wosWOS:001348849800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Materials Science-Materials in Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectIntrabony Defects
dc.subjectT-Prf
dc.subjectTechnologies
dc.subjectBiomaterials
dc.subjectImplant
dc.titleNano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
dc.typeArticle

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