Immunohistochemical investigation of histopathological changes in the kidney tissue of mussel-fed rats

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dc.contributor.authorIrkin, Latife Ceyda
dc.contributor.authorOrturk, Samil
dc.date.accessioned2025-01-27T20:47:27Z
dc.date.available2025-01-27T20:47:27Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The aim of this study was to determine the histopathological changes that the mussels, which serve as important filters of the sea, cause in rat kidney tissue. Materials and Methods: In our study, 24 female (Wistar albino 6-10 week old rats) rats were used. First group (n: 6): fed with standard rat food, second group (n: 6): fed everyday with 4/5 mussels + 1/5 standard rat food; third group (n: 6): fed 4/5 mussels + 1/5 standard rat food every two days; Fourth group (n: 6): were formed with 4/5 mussels + 1/5 standard rat food to be given every three days. After the routine histopathological follow-up, all kidney tissue samples taken and control groups were analyzed with Hematoxylin-Eosin staining, and the nephrotoxic effect was immunohistochemically with TGF-beta and NF-kappa B and analyzed with a light microscope image analysis system. Results: Mussel-fed rats were found to cause inflammation in the kidney tissue, dilatation in the distal and proximal tubules, shrinkage in the glomeruli and degeneration in the tubular epithelium. In immunohistochemical staining, TGF-beta and NF-kappa B immunoreactivity increased due to cells leading to inflammation and apoptosis. The nephrotoxic effect was quite high especially in rats given daily mussels. Conclusion: The mussel provided in unsanitary conditions may cause damage in kidney tissue from the excretory system organs due to excess consumption.
dc.identifier.doi10.17826/cumj.790895
dc.identifier.endpage1782
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue4
dc.identifier.startpage1775
dc.identifier.trdizinid1115799
dc.identifier.urihttps://doi.org/10.17826/cumj.790895
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1115799
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24913
dc.identifier.volume45
dc.identifier.wosWOS:000609003200059
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNephrotoxicity
dc.subjectkidney
dc.subjectmussel
dc.subjectimmunohistochemistry
dc.titleImmunohistochemical investigation of histopathological changes in the kidney tissue of mussel-fed rats
dc.typeArticle

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