EVALUATION OF EPICARDIAL FAT TISSUE THICKNESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM

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dc.authoridsahin, sinan/0000-0002-3687-0580
dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.contributor.authorAsik, Mehmet
dc.contributor.authorSahin, Sinan
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorOzkaya, Mesut
dc.contributor.authorOzkul, Faruk
dc.contributor.authorSen, Hacer
dc.contributor.authorBinnetoglu, Emine
dc.date.accessioned2025-01-27T20:39:21Z
dc.date.available2025-01-27T20:39:21Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Primary hyperparathyroidism (pHPT) affects the cardiovascular system, and epicardial fat tissue (EFT) thickness is closely associated with cardiovascular diseases and atherosclerosis. Despite this, the association between EFT thickness and pHPT has not been studied in a clinical setting. This study aimed to assess EFT thickness in patients with pHPT. Methods: The study included 38 patients with pHPT and 40 healthy controls. EFT thickness, carotid intimamedia thickness (CIMT), serum levels of parathormone (PTH) and calcium, and blood chemistry profiles were determined in all subjects. Correlation and regression analyses were performed with EFT thickness and CIMT as dependent variables and age; systolic and diastolic blood pressure; body mass index (BMI); presence of diabetes mellitus; and free plasma glucose (FPG), PTH, and serum calcium (Ca) levels as independent variables. Results: Both the mean EFT thickness and the mean CIMT were significantly greater in the pHPT group than the control group (P<.001 for both). Correlation analysis showed that EFT thickness was significantly correlated with CIMT, age, systolic blood pressure, and PTH and serum Ca levels. Furthermore, the regression analysis revealed that EFT thickness retained its independent and positive association with FPG and serum Ca levels. Conclusions: The results of this study indicate that EFT thickness may be a useful marker of early atherosclerosis in patients with pHPT. Furthermore, the increase in EFT thickness appears to be due to hypercalcemia.
dc.identifier.doi10.4158/EP13140.OR
dc.identifier.endpage32
dc.identifier.issn1530-891X
dc.identifier.issn1934-2403
dc.identifier.issue1
dc.identifier.pmid24013988
dc.identifier.scopus2-s2.0-84892692174
dc.identifier.scopusqualityQ1
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.4158/EP13140.OR
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23926
dc.identifier.volume20
dc.identifier.wosWOS:000329913500009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Assoc Clinical Endocrinologists
dc.relation.ispartofEndocrine Practice
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectIntima-Media Thickness
dc.subjectCoronary-Artery-Disease
dc.subjectMild Primary Hyperparathyroidism
dc.subjectCarotid-Artery
dc.subjectCardiovascular-Disease
dc.subjectAdipose-Tissue
dc.subjectRisk-Factors
dc.subjectHeart-Disease
dc.subjectAtherosclerosis
dc.subjectWall
dc.titleEVALUATION OF EPICARDIAL FAT TISSUE THICKNESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM
dc.typeArticle

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