Drug-impregnated contact lenses via supercritical carbon dioxide: A viable solution for the treatment of bacterial and fungal keratitis

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dc.authoridGüngör, Buket / 0000-0002-5802-1635
dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.authoridErdoğan, Hakika / 0000-0001-7749-2814
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorGüngör, Buket
dc.contributor.authorErdoğan, Hakika
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorSılan, Coşkun
dc.contributor.authorSaraydın, Serpil U.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:59:45Z
dc.date.available2025-01-27T20:59:45Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractKeratitis is a corneal infection caused by various bacteria and fungi. Eye drop treatment of keratitis involves significant challenges due to difficulties in administration, inefficiencies in therapeutic dosage, and frequency of drug applications. All these are troublesome and result in unsuccessful treatment, high cost, time loss, development of drug resistance by microorganisms, and a massive burden on human health and the healthcare system. Most of the antibacterial and antifungal medications are non-water-soluble and/or include toxic drug formulations. Here, the aim was to develop drug-loaded contact lenses with therapeutic dosage formulations and extended drug release capability as an alternative to eye drops, by employing supercritical carbon dioxide (ScCO2) as a drug impregnation solvent to overcome inefficient ophthalmic drug use. ScCO2, known as a green solvent, has very low viscosity which provides high mass transfer power and could enhance drug penetration into contact lenses much better with respect to drug loading using other solvents. Here, moxifloxacin (MOX) antibiotic and amphotericin B (AMB) antifungal medicines were separately loaded into commercially available silicone hydrogel contact lenses through 1) drug adsorption from the aqueous solutions and 2) impregnation techniques via ScCO2 and their efficacies were compared. Drug impregnation parameters, i.e., 8-25 MPa pressure, 310-320 K temperature, 2-16-hour impregnation times, and the presence of ethanol as polar co-solvent were investigated for the optimization of the ScCO2 drug impregnation process. The highest drug loading and long-term release kinetic from the contact lenses were obtained at 25 MPa and 313 K with 2.5 h impregnation time by using 1 % ethanol (by volume). Furthermore, antibacterial/antifungal activities of the MOX- and AMBimpregnated contact lenses were effective against in vitro Pseudomonas aeruginosa (ATCC 10145) bacteria and Fusarium solani (ATCC 36031) fungus for up to one week. Consequently, the ScCO2 method can be effectively used to impregnate commercial contact lenses with drugs, and these can then be safely used for the treatment of keratitis. This offers a sustainable delivery system at effective dosage formulations with complete bacterial/ fungal inhibition and termination, making it viable for real animal/human applications.
dc.description.sponsorshipTUBITAK [122 M641]
dc.description.sponsorshipThe support from TUBITAK (122 M641) is greatly appreciated.
dc.identifier.doi10.1016/j.ijpharm.2024.124505
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmid39059520
dc.identifier.scopus2-s2.0-85199699509
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2024.124505
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26814
dc.identifier.volume662
dc.identifier.wosWOS:001285499600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDrug-loaded contact lenses
dc.subjectDrug impregnation
dc.subjectSupercritical carbon dioxide
dc.subjectKeratitis treatment
dc.titleDrug-impregnated contact lenses via supercritical carbon dioxide: A viable solution for the treatment of bacterial and fungal keratitis
dc.typeArticle

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