Relationship Between Bilirubin Level and Disease Activity in Crohn's Disease

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dc.contributor.authorSen, Hacer
dc.contributor.authorAkbal, Erdem
dc.contributor.authorErbag, Gokhan
dc.contributor.authorBinnetoglu, Emine
dc.date.accessioned2025-01-27T20:49:41Z
dc.date.available2025-01-27T20:49:41Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal system. Regarding its pathogenesis, it is known that transmural inflammation develops in the bowel. In recent years, it has been considered that bowel damage occurs as a consequence of an imbalance between oxidative stress and ischaemia and antioxidant capacity. Bilirubin is the metabolic product that develops as a result of heme destruction. In oxidative stress, blood bilirubin levels increase in correlation with the intensity of ischaemia. The aim of our study was to evaluate the potential of bilirubin as a serum factor to be a marker of disease activity of CD. Material and Method: Thirty patients diagnosed with active CD and 66 healthy control subjects were involved in the study. Clinical activity was determined using the Crohn's Disease Activity Index (CDAI). Serum bilirubin levels of active disease and remission periods were compared with the control group. Results: When total bilirubin values were examined, the bilirubin level among Crohn's disease patients was significantly increased compared to the control group (p < 0.05). The total bilirubin value exhibited significant alteration during the remission period (p < 0.05). Discussion: Our study showed that serum bilirubin was increased in active CD patients compared to controls.
dc.identifier.doi10.4328/JCAM.4506
dc.identifier.endpage30
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.scopus2-s2.0-85015427915
dc.identifier.scopusqualityN/A
dc.identifier.startpage27
dc.identifier.urihttps://doi.org/10.4328/JCAM.4506
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25279
dc.identifier.volume7
dc.identifier.wosWOS:000396410400037
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherDerman Medical Publ
dc.relation.ispartofJournal of Clinical and Analytical Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCrohn's Disease
dc.subjectBilirubin
dc.subjectCrohn's Disease Activity Index
dc.subjectInflammation
dc.titleRelationship Between Bilirubin Level and Disease Activity in Crohn's Disease
dc.title.alternativeCrohn hastalığında bilirübin düzeyi ile hastalık aktivitesi arasında İlişki
dc.typeArticle

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