The effects of systemic ozone application and hyperbaric oxygen therapy on avascular necrosis of the femoral head: An experimental study in the vascular deprivation of the rat femoral head model

dc.authoridErken, Hüseyin Yener / 0000-0001-7937-7203
dc.authoridİçkin Gülen, Meltem / 0000-0002-6364-8344
dc.authoridGüven Bağla, Aysel / 0000-0001-7511-7105
dc.authoridKuru, Tolgahan / 0000-0003-1245-6390
dc.contributor.authorYılmaz, Onur
dc.contributor.authorErken, Hüseyin Yener
dc.contributor.authorİçkin Gülen, Meltem
dc.contributor.authorGüven Bağla, Aysel
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorKuru, Tolgahan
dc.date.accessioned2025-05-29T02:54:18Z
dc.date.available2025-05-29T02:54:18Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study aims to assess the effects of systemic medical ozone (O3) application and to compare its effects with hyperbaric oxygen (HBO) therapy for preventing avascular necrosis of the femoral head in a rat model. Materials and methods: A total of 50 male Wistar albino rats were divided into six groups including five rats in each control and sham-operated control group and 10 rats in the remaining four groups: (i) control group, (ii) sham-operated control group, (iii) avascular necrosis group, (iv) intraperitoneal ozone given avascular necrosis group, (v) HBO therapy given avascular necrosis group, and (vi) intraperitoneal ozone and HBO given avascular necrosis group. We surgically induced osteonecrosis by cutting the ligamentum teres and placing a tight ligature around the femoral neck. At Week 11, we harvested femoral heads bilaterally from each animal and performed a macroscopic, histological evaluation and histomorphometric, immunohistochemical analysis. Results: The intertrabecular mesenchymal cell ratio was substantially higher in the O3 group than that of all other groups in the histological evaluation (p<0.05). Group O3 had also significantly more CD31-positive stained new vasculature than other groups, with the exception of the HBO therapy group, according to the immunohistochemical analysis (p<0.05). Conclusion: The results of this experimental study suggest that the application of medical ozone alone may have a positive effect on new vessel formation and the repair process and may be more beneficial than HBO therapy and HBO+O3 therapy in the vascular deprivation of the rat femoral head model. © 2025 All right reserved by the Turkish Joint Diseases Foundation
dc.description.sponsorshipÇanakkale Onsekiz Mart Üniversitesi, ÇOMÜ, (THD-2020-3189)
dc.description.sponsorshipÇanakkale Onsekiz Mart Üniversitesi, ÇOMÜ
dc.identifier.doi10.52312/JDRS.2025.1959
dc.identifier.endpage303
dc.identifier.issn2687-4792
dc.identifier.issue2
dc.identifier.pmid40235407
dc.identifier.scopus2-s2.0-105003616779
dc.identifier.scopusqualityQ2
dc.identifier.startpage293
dc.identifier.urihttps://doi.org/10.52312/JDRS.2025.1959
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29985
dc.identifier.volume36
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250529
dc.subjectAvascular necrosis
dc.subjectfemoral head
dc.subjecthyperbaric oxygen
dc.subjectosteonecrosis
dc.subjectozone
dc.titleThe effects of systemic ozone application and hyperbaric oxygen therapy on avascular necrosis of the femoral head: An experimental study in the vascular deprivation of the rat femoral head model
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Yükleniyor...
Küçük Resim
İsim:
Huseyin Yener Erken_Makale.pdf
Boyut:
1.41 MB
Biçim:
Adobe Portable Document Format