Magnesium Bromide and Magnesium Chloride Hexahydrate Catalyzed One-Pot Synthesis of Dihydropyrimidines via Biginelli Reaction under Solvent-Free Conditions

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dc.contributor.authorGulten, Sirin
dc.date.accessioned2025-01-27T20:17:07Z
dc.date.available2025-01-27T20:17:07Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBiologically important 12 new important 3,4-dihydropyrimidin-2-(1H)-ones (-thiones) were synthesized with in one-pot three-component Biginelli reaction from the corresponding aromatic aldehydes (5-methyl-2-thiophenecarboxaldehyde and 2-chloro-5-nitrobenzaldehyde), -keto esters (ethylacetoacetate, allylacetoacetate, and t-butylacetoacetate), and urea/thiourea in the presence of catalytic amount of magnesium bromide and magnesium chloride hexahydrate as nontoxic, inexpensive, and easily available catalysts under solvent-free conditions at 80 and 100 degrees C. Compared with the catalyst-free three-component Biginelli reaction conditions, this method consistently has the advantage of short reaction time (45100 min) and good to excellent yields (7591%).
dc.description.sponsorshipCanakkale Onsekiz Mart University [BAP 2008/28]
dc.description.sponsorshipThe author thanks to Canakkale Onsekiz Mart University (BAP 2008/28) for financial support. The author also thanks to NMR Analysis Laboratory of Hacettepe University for recording NMR spectra and Central Laboratory of Pharmacy, Ankara University, for the measurement of the mass spectra and elemental microanalyses.
dc.identifier.doi10.1002/jhet.980
dc.identifier.endpage395
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84876938396
dc.identifier.scopusqualityQ2
dc.identifier.startpage391
dc.identifier.urihttps://doi.org/10.1002/jhet.980
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21493
dc.identifier.volume50
dc.identifier.wosWOS:000318293000034
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCalcium-Channel Blockers
dc.subjectSmall-Molecule Inhibitor
dc.subjectAcid-Esters
dc.subjectConformational-Analysis
dc.subjectMitotic Kinesin
dc.subjectEfficient
dc.subjectDerivatives
dc.subjectFacile
dc.subject3,4-Dihydropyrimidin-2-(1h)-Ones
dc.subject3-Component
dc.titleMagnesium Bromide and Magnesium Chloride Hexahydrate Catalyzed One-Pot Synthesis of Dihydropyrimidines via Biginelli Reaction under Solvent-Free Conditions
dc.typeArticle

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