Relationship between serum fibronectin levels and carnitine administration: an experimental study in rats

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dc.contributor.authorOzkan, Omer F.
dc.contributor.authorKomurcu, Erkam
dc.contributor.authorArik, Muhammet K.
dc.contributor.authorKemik, Ahu S.
dc.contributor.authorTas, Sukru
dc.contributor.authorNusran, Gurdal
dc.date.accessioned2025-01-27T20:58:12Z
dc.date.available2025-01-27T20:58:12Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe aimed to investigate the relationship between dorsal flap viability and serum fibronectin levels in carnitine-administered rats. A total of 24 rats were equally divided into three groups and operated on. Group 1 (sham group n = 8): following surgery, no agent was given. Group 2 (control group, n = 8): following surgery, sterile saline solution at 09% with a dose of 100 mg/kg per day for 7 days was administered intraperitoneally. Group 3 (study group, n = 8): following surgery, carnitine with a dose of 100 mg/kg per day for 7 days was administered intraperitoneally. The flap model used was a 10 x 3 cm dorsal flap extending from the tip of the scapula to the hip joint. This was elevated, and then sutured back to its original site. At the end of postoperative day 8, the animals were anaesthetised and blood samples were collected from intracardiac space. Then, the animals were euthanised. Flap viability was then evaluated measuring the surviving area, using a transparent graph paper. Finally, excised tissue was examined histopathologically. The percentages of viable areas in groups 1, 2 and 3 were 6468 +/- 337%, 6735 +/- 582% and 7515 +/- 356%, respectively. The mean value of fibronectin levels in groups 1, 2 and 3 were 223 +/- 35, 231 +/- 35 and 31 +/- 68 mg/dl, respectively. The results of this study demonstrated that 100 mg/kg carnitine administration led to an increase in flap viability, and increased serum fibronectin levels might have a role in this process.
dc.identifier.doi10.1111/iwj.12036
dc.identifier.endpage722
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.issue6
dc.identifier.pmid23369036
dc.identifier.scopus2-s2.0-84911805964
dc.identifier.scopusqualityQ1
dc.identifier.startpage718
dc.identifier.urihttps://doi.org/10.1111/iwj.12036
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26641
dc.identifier.volume11
dc.identifier.wosWOS:000345509700024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Wound Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectFibronectin
dc.subjectCarnitine flap viability
dc.titleRelationship between serum fibronectin levels and carnitine administration: an experimental study in rats
dc.typeArticle

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