Can Glypican-6 Levels Be Used to Determine Right Ventricular Remodeling After Non-ST Segment Elevation Myocardial Infarction?

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dc.contributor.authorKucuk, Ugur
dc.contributor.authorVolina, Emir
dc.contributor.authorArslan, Kadir
dc.date.accessioned2025-01-27T20:26:59Z
dc.date.available2025-01-27T20:26:59Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Myocardial infarction is associated with right ventricular (RV) remodeling. Glypican-6 (GPC6), a member of the membrane proteoglycan family, plays a significant role in cardiac remodeling. This study aims to determine if GPC6 can predict RV remodeling after percutaneous coronary intervention (PCI) in patients with non-ST segment elevation myocardial infarction (NSTEMI). Methods: The study enrolled 164 consecutive patients with NSTEMI and controls. It compared baseline plasma GPC6 levels, echocardiography, and laboratory parameters between the RV remodeling and non-RV remodeling groups with NSTEMI. Echocardiographic data were measured at baseline and at six months. Results: GPC6 levels were higher in the NSTEMI group 11.06 ng/mL (4.61-18.17) vs. 5.98 ng/ mL (3.81-9.83) compared to the control group in the initial phase. RV remodeling, defined as a >= 20% increase in RV end-diastolic area (RV EDA), was observed in 23 patients (30%). After six months, RV EDA increased significantly from baseline 18.68 +/- 1.20 cm2 2 vs. 24.91 +/- 1.08 cm(2),P < 0.001. GPC6 was a significant independent predictor of RV remodeling (hazard ratio [HR]: 1.546, 95% confidence interval [CI]: 1.056-2.245, P < 0.001). Receiver operating characteristic curve (ROC) analyses showed that GPC6 values > 15.5 ng/mL (area under the curve [AUC] = 0.828, sensitivity: 70%, specificity: 74%, P < 0.001) were strong predictors of RV remodeling. Conclusion: NSTEMI patients should be closely monitored for RV remodeling. GPC6 appears useful in detecting RV remodeling following NSTEMI in patients undergoing PCI.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [THD-2022-4174]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit (Project number: THD-2022-4174) .
dc.identifier.doi10.5543/tkda.2024.15672
dc.identifier.endpage314
dc.identifier.issn1016-5169
dc.identifier.issn1308-4488
dc.identifier.issue5
dc.identifier.pmid38982813
dc.identifier.scopus2-s2.0-85198451662
dc.identifier.scopusqualityQ3
dc.identifier.startpage307
dc.identifier.urihttps://doi.org/10.5543/tkda.2024.15672
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22532
dc.identifier.volume52
dc.identifier.wosWOS:001302643900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectGlypican-6
dc.subjectright ventricular (RV) remodeling
dc.subjectnon-ST segment elevation myocardial infarction (NSTEMI)
dc.subjectright ventricle
dc.titleCan Glypican-6 Levels Be Used to Determine Right Ventricular Remodeling After Non-ST Segment Elevation Myocardial Infarction?
dc.title.alternativeGlypican-6 Düzeyleri ST Elevasyonu Olmayan Miyokard Enfarktüsü Sonrası Sağ Ventrikül Yeniden Şekillenmesinin Belirlenmesinde Kullanılabilir Mi?
dc.typeArticle

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