Synthesis, Hydrolytic Degradation Behavior, and Surface Properties of Poly(alkyl glycolide)-Polyglycolide Copolymers

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dc.authoridCengiz, Ugur/0000-0002-0400-3351
dc.authoridMert, Serap/0000-0001-5939-5295
dc.contributor.authorBamyaci, Mehtap Canturk
dc.contributor.authorCetin, Duygu
dc.contributor.authorCengiz, Candan
dc.contributor.authorBelen, Sema Nur
dc.contributor.authorMert, Olcay
dc.contributor.authorCengiz, Ugur
dc.contributor.authorMert, Serap
dc.date.accessioned2025-05-29T02:57:50Z
dc.date.available2025-05-29T02:57:50Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGiven the environmental impact of polymers on our daily lives, the development of biodegradable polymers is becoming increasingly critical. Poly(diisobutyl glycolide)-polyglycolide (PDIBG-PGA) and poly(diisopropyl glycolide)-polyglycolide (PDIPG-PGA) copolymers, which are structurally similar to polylactic-co-glycolic acid (PLGA) polyesters frequently used in the field of biomaterials, were synthesized via ring-opening polymerization (ROP) of glycolide with l-diisobutyl glycolide (l-DIBG) or l-diisopropyl glycolide (l-DIPG), respectively, in various molecular weights (M w GPC: 15.5-40.0 kDa) and in high yields (up to 85.0%). The wettability characteristics of biodegradable polymers are important not only in air but also for their behavior in underwater environments. PDIBG-PGA silica composites, due to their amphiphilic nature, exhibited water contact angles between 72 degrees and 85 degrees in air, unaffected by the increasing addition of hydrophilic silica nanoparticles. However, underwater-oil contact angles increased from 75 degrees to 165 degrees as a result of the higher silica nanoparticle content and enhanced surface roughness. When the silica content reached 30%, the surface demonstrated self-cleaning and oil-repellent properties underwater, attributed to the Cassie state, which trapped air within the surface's hierarchical roughness. Furthermore, the surface free energy (SFE) values of PDIBG-PGA and PDIPG-PGA copolymer films were evaluated using the Owens-Wendt method, which revealed an increasing underwater hexadecane contact angle as the polar component interactions increased. Differential scanning calorimetry analysis revealed that all synthesized copolymers were amorphous, and the glass transition temperatures (T g) increased with the increase in the molecular weight of the copolymers (for instance, M n GPC: 9560 g/mol -> T g: 25.1 degrees C vs M n GPC: 20,850 g/mol -> T g: 32.3 degrees C for PDIBG-PGA; M n GPC: 10,670 g/mol -> T g: 37.7 degrees C vs M n GPC: 23,360 g/mol -> T g: 42.3 degrees C for PDIPG-PGA). The molecular weight decreases of 88.3% and 76.5% and mass losses of 36.7% and 12.3% were observed for PDIBG-PGA and PDIPG-PGA copolymers after 8 weeks of hydrolytic degradation, respectively. The faster degradation of PDIBG-PGA (T g: 25.1 degrees C) than PDIPG-PGA (T g: 37.7 degrees C) may be attributed to the T g below the hydrolytic degradation temperature (37 degrees C) because of an increase in the mobility of PDIBG-PGA polymer chains, allowing water molecules to transfer more easily through the matrix.
dc.description.sponsorshipKocaeli niversitesi [FDK-2022-2844]; Kocaeli University Scientific Research Project Coordination Unit within Project
dc.description.sponsorshipThis study was financially supported by Kocaeli University Scientific Research Project Coordination Unit within Project Number: FDK-2022-2844.
dc.identifier.doi10.1021/acsomega.4c10768
dc.identifier.endpage8511
dc.identifier.issn2470-1343
dc.identifier.issue8
dc.identifier.pmid40060789
dc.identifier.scopus2-s2.0-86000431447
dc.identifier.scopusqualityQ1
dc.identifier.startpage8499
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c10768
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30190
dc.identifier.volume10
dc.identifier.wosWOS:001427023200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectSubstituted Glycolides
dc.subjectWater Droplet
dc.subjectDrug
dc.subjectPlga
dc.subjectAcid
dc.titleSynthesis, Hydrolytic Degradation Behavior, and Surface Properties of Poly(alkyl glycolide)-Polyglycolide Copolymers
dc.typeArticle

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