Inhibitory Effects of Spirulina platensis on Carcinogen-Activating Cytochrome P450 Isozymes and Potential for Drug Interactions

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dc.contributor.authorSavranoglu, Seda
dc.contributor.authorTumer, Tugba Boyunegmez
dc.date.accessioned2025-01-27T20:38:55Z
dc.date.available2025-01-27T20:38:55Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSpirulina platensis (SP) has been considered as potential food source of 21st century due to its remarkable nutrient profile and therapeutic benefits. However, the cytochrome P450 (CYP)-mediated drug/chemical interaction potential of SP has not yet been pursued. We investigated the effects of SP on the expressions and enzymatic activities of main CYP isozymes. After the rats were orally administered with SP daily for 5 consecutive weeks, there were significant downregulations in hepatic expression levels and inhibition in enzymatic activities of CYP1A2 and CYP2E1 compared to controls. In addition, a significant decrease was observed in CYP2C6-associated enzyme activity with no remarkable changes in messenger RNA (mRNA)/protein levels. The SP application resulted in significant increases in mRNA/protein levels of both CYP2B1 and CYP3A1 without a significant change in enzyme activities. These findings partly explain the chemopreventive properties of SP toward various organ toxicities, mutagenesis, and carcinogenesis; however, its coadministration with some CYP substrates may lead to undesirable drug interactions.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [111T582]
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a grant from the Scientific and Technological Research Council of Turkey (Project No. 111T582).
dc.identifier.doi10.1177/1091581813503887
dc.identifier.endpage384
dc.identifier.issn1091-5818
dc.identifier.issn1092-874X
dc.identifier.issue5
dc.identifier.pmid24082030
dc.identifier.scopus2-s2.0-84887840090
dc.identifier.scopusqualityQ3
dc.identifier.startpage376
dc.identifier.urihttps://doi.org/10.1177/1091581813503887
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23802
dc.identifier.volume32
dc.identifier.wosWOS:000326330200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofInternational Journal of Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSpirulina platensis
dc.subjectcytochrome P450
dc.subjectdrug interaction
dc.subjectchemoprevention
dc.titleInhibitory Effects of Spirulina platensis on Carcinogen-Activating Cytochrome P450 Isozymes and Potential for Drug Interactions
dc.typeArticle

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