A novel biosensing system based on ITO-single use electrode for highly sensitive analysis of VEGF

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dc.authoridAkgun, Mert/0000-0002-9878-8566
dc.contributor.authorAkgun, Mert
dc.contributor.authorKemal Sezginturk, Mustafa
dc.date.accessioned2025-01-27T20:29:00Z
dc.date.available2025-01-27T20:29:00Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNowadays, breast cancer is one of the riskiest and common cancer types. The early diagnosis of breast cancer is very important just as in other cancer types. Recent investigations demonstrate the biomarkers can be useful for the disease phase. These biomarkers are the very important materials to determine the good or bad diagnostic of the patient. Vascular endothelial growth factor is considered the most powerful mitogen for endothelial cells and also is an important regulator of vascular permeability and angiogenesis. In the frame of this study, it is purposed to design an electrochemical immunosensor system based on indium-tin oxide covered polyethylene terephthalate electrode. Electrochemical impedance spectroscopy, which is a quick and sensitive method, was used for vascular endothelial growth factor determination. Electrochemical impedance spectroscopy and cyclic voltammetry techniques were used in all optimisation processes of the produced biosensor. Scanning electron microscopy images, energy-dispersive X-ray spectra and mapping, atomic force microscopy and infrared spectra were examined to support the optimisation studies and to reveal surface morphology and chemical components. In the electrochemical characterisation studies, repeatability, reproducibility, storage, regeneration, single frequency impedance, square wave voltammetry and Kramer's-Kronig transform studies were performed. The measurements were taken in human serum.
dc.description.sponsorshipCanakkale Onsekiz Mart University Council of Scientific Research Project [FYL-2018-1376]
dc.description.sponsorshipThis work was funded by Canakkale Onsekiz Mart University Council of Scientific Research Project [Project number: FYL-2018-1376].
dc.identifier.doi10.1080/03067319.2019.1709637
dc.identifier.endpage450
dc.identifier.issn0306-7319
dc.identifier.issn1029-0397
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85077842953
dc.identifier.scopusqualityQ1
dc.identifier.startpage432
dc.identifier.urihttps://doi.org/10.1080/03067319.2019.1709637
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22776
dc.identifier.volume100
dc.identifier.wosWOS:000505140100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Environmental Analytical Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectITO-PET electrode
dc.subjectVEGF-R1
dc.subjectbiosensor
dc.subjectbreast cancer
dc.titleA novel biosensing system based on ITO-single use electrode for highly sensitive analysis of VEGF
dc.typeArticle

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