Predictive value of standard serum markers for bone metastases in prostate cancer

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dc.authorid0000-0003-1302-9630en_US
dc.authorid0000-0002-9847-9421en_US
dc.authorid0000-0003-1551-4998en_US
dc.authorscopusid57197259576en_US
dc.authorscopusid55935770400en_US
dc.authorscopusid57223347286en_US
dc.authorwosidGYE-5957-2022en_US
dc.authorwosidCOI-5166-2022en_US
dc.authorwosidDVR-5149-2022en_US
dc.contributor.authorÖzdemir, Semra
dc.contributor.authorErsay, Ahmet Reşit
dc.contributor.authorKoç Öztürk, Fulya
dc.contributor.authorÖzdemir, Beril Su
dc.date.accessioned2023-03-14T11:22:28Z
dc.date.available2023-03-14T11:22:28Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackgroundThe early detection of bone metastases is very important in prostate cancer follow-up. This study aimed to compare conventional tumor markers, namely free prostate-specific antigen (free PSA), total prostate-specific antigen (total PSA), free PSA/total PSA ratio, alkaline phosphatase (ALP) values, Gleason scores and (99 m) Tc-MDP bone scintigraphy findings in the prediction of bone metastases in prostate cancer.MethodsIn total, 175 patients with prostate cancer who underwent whole-body bone scintigraphy were included in the study. All selected scintigraphic studies were reprocessed. Free PSA, total PSA, free PSA/total PSA ratio, alkaline phosphatase (ALP) values and Gleason scores of patients were recorded.ResultsThe results of our study show that the presence of bone metastasis correlates very weakly with free PSA/total PSA ratio (rho=0.179), weakly with total PSA (rho=0.318) and Gleason score (rho=0.382), moderately with ALP (rho=0.539), free PSA (0.416). Only ALP variable had a diagnostic value and ALP cutoff value was 76.50 IU/L, with 80% sensitivity and 82.1% specificity.ConclusionAccording to the results of our study; the free PSA, total PSA, free PSA/total PSA ratio and Gleason score values were not considered as a reliable parameter in the prostate cancer cases follow-up for bone metastasis development. Only ALP had a diagnostic value and ALP cutoff value was 76.50 IU / L with 80% sensitivity and 82.1% specificity in predicting bone metastases in prostate cancer.en_US
dc.identifier.citationOzdemir, S., Ersay, A. R., Koc Ozturk, F., & Ozdemir, B. S. (2021). Predictive value of standard serum markers for bone metastases in prostate cancer. African Journal of Urology, 27(1) doi:10.1186/s12301-021-00170-wen_US
dc.identifier.doi10.1186/s12301-021-00170-w
dc.identifier.endpage6en_US
dc.identifier.issn1110-5704
dc.identifier.issn1961-9987
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85105626277
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1186/s12301-021-00170-w
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3798
dc.identifier.volume27en_US
dc.identifier.wosWOS:000761689300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzdemir, Semra
dc.institutionauthorErsay, Ahmet Reşit
dc.institutionauthorKoç Öztürk, Fulya
dc.language.isoen
dc.publisherSpringerOpenen_US
dc.relation.ispartofAfrican Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone Scintigraphyen_US
dc.subjectFree/Total PSAen_US
dc.subjectProstate Canceren_US
dc.titlePredictive value of standard serum markers for bone metastases in prostate cancer
dc.typeArticle

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