Differential pulse voltammetric determination of acyclovir in pharmaceutical preparations using a pencil graphite electrode

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dc.authoridGiray Dilgin, Didem/0000-0002-3487-3470
dc.authoridKarakaya, Serkan/0000-0002-6401-3295
dc.contributor.authorDilgin, Didem Giray
dc.contributor.authorKarakaya, Serkan
dc.date.accessioned2025-01-27T20:50:11Z
dc.date.available2025-01-27T20:50:11Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, a new selective and sensitive voltammetric procedure for determination of acyclovir (ACV) was proposed using a disposable electrode, pencil graphite electrode (PGE). Cyclic and differential pulse voltammograms of ACV were recorded in Britton-Robinson buffer solution containing 0.10 M KCI with pH of 4.0 at PGE. The PGE displayed a very good electrochemical behavior with significant enhancement of the peak current compared to a glassy carbon electrode (GCE). Under experimental conditions, the PGE had a linear response range from 1.0 mu M to 100.0 mu M ACV with a detection limit of 0.3 mu M (based on 3 S-b). Relative standard deviations of 4.8 and 3.6% were obtained for five successive determinations of 10.0 and 50.0 mu M ACV, respectively, which indicate acceptable repeatability. This voltammetric method was successfully applied to the direct determination of ACV in real pharmaceutical samples. The effect of various interfering compounds on the ACV peak current was studied. (C) 2016 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.msec.2016.02.079
dc.identifier.endpage576
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid27040252
dc.identifier.scopus2-s2.0-84961231327
dc.identifier.scopusqualityN/A
dc.identifier.startpage570
dc.identifier.urihttps://doi.org/10.1016/j.msec.2016.02.079
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25432
dc.identifier.volume63
dc.identifier.wosWOS:000374916800064
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPencil graphite electrode
dc.subjectAcyclovir
dc.subjectDifferential pulse voltammetry
dc.titleDifferential pulse voltammetric determination of acyclovir in pharmaceutical preparations using a pencil graphite electrode
dc.typeArticle

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