Extremely low frequency magnetic fields cause oxidative DNA damage in rats

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dc.authoridDasdag, Suleyman/0000-0003-1211-9677
dc.contributor.authorYokus, Beran
dc.contributor.authorAkdag, M. Zulkuf
dc.contributor.authorDasdag, Suleyman
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorKizil, Murat
dc.date.accessioned2025-01-27T20:20:38Z
dc.date.available2025-01-27T20:20:38Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To detect the genotoxic effects of extremely low frequency (ELF) -magnetic fields (MF) on oxidative DNA base modifications [8-hydroxyguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde)] in rat leucocytes, measured following exposure to ELF-MF. Materials and methods: After exposure to ELF-MF (50Hz, 100 and 500 mu T, for 2 hours/day during 10 months), DNA was extracted, and measurement of DNA lesions was achieved by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). Results: Levels of FapyAde, FapyGua and 8OHdG in DNA were increased by both 100 mu T and 500 mu T ELF-MF as compared to a cage-control and a sham group; however, statistical significance was observed only in the group exposed to 100 mu T. Conclusion: This is the first study to report that ELF-MF exposure generates oxidatively induced DNA base modifications which are mutagenic in mammalian cells, such as FapyGua, FapyAde and 8-OH-Gua, invivo. This may explain previous studies showing DNA damage and genomic instability. These findings support the hypothesis that chronic exposure to 50-Hz MF may be potentially genotoxic. However, the intensity of ELF-MF has an important influence on the extent of DNA damage.
dc.identifier.doi10.1080/09553000802348203
dc.identifier.endpage795
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue10
dc.identifier.pmid18979312
dc.identifier.scopus2-s2.0-55349145975
dc.identifier.scopusqualityQ2
dc.identifier.startpage789
dc.identifier.urihttps://doi.org/10.1080/09553000802348203
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21770
dc.identifier.volume84
dc.identifier.wosWOS:000260573400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDNA damage
dc.subjectextremely low frequency magnetic field
dc.subject8-hydroxy-2'-deoxyguanosine
dc.subject8-hydroxyguanine
dc.subject2
dc.subject6-diamino-4-hydroxy-5-formamidopyrimidine
dc.subject4
dc.subject6-diamino-5-formamidopyrimidine
dc.titleExtremely low frequency magnetic fields cause oxidative DNA damage in rats
dc.typeArticle

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