Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand

Basit Öğe Kaydı
dc.authoridNeshat, Abdollah/0000-0002-1424-2292
dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridKARABIYIK, Talha/0000-0002-1339-7348
dc.contributor.authorAghatabay, Naz M.
dc.contributor.authorNeshat, A.
dc.contributor.authorKarabiyik, T.
dc.contributor.authorSomer, M.
dc.contributor.authorHaciu, D.
dc.contributor.authorDulger, B.
dc.date.accessioned2025-01-27T20:14:21Z
dc.date.available2025-01-27T20:14:21Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstract2,6-Bis(benzimidazol-2-yl)pyridine (L) ligand and complexes [M(L)Cl-2] and [Fe(L)(2)](ClO4)(2) (M = Zn, Cd, Hg) have been synthesized. The,geometries of the [M(L)Cl-2] complexes were derived from theoretical calculation in DGauss/DFT level (DZVP basis set) on CACHE. The central M(II) ion is penta-coordinated and surrounded by N3Cl2 environment, adopting a distorted trigonal bipyramidal geometry. The ligand is tridentate, via three nitrogen atoms to metal centre and two chloride ions lie on each side of the distorted benzimidazole ring. In the [Fe(L)21 (ClO4)(2) complex, the central Fe(H) ion is surrounded by two (3N) units, adopting a octahedral geometry. The elemental analysis, molecular conductivity, FT-Raman, FT-IR (mid-, far-IR), H-1, and C-13 NMR were reported. The antimicrobial activities of the free ligand, its hydrochloride salt, and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against 10 bacteria and the results compared with that for gentamycin. Antifungal activities were reported for Candida albicans, Khtyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, Hanseniaspora guilliemondii, and the results were referenced against nystatin, ketaconazole, and clotrimazole antifungal agents. In most cases, the compounds tested showed broad-spectrum (Gram positive and Gram negative bacteria) activities that were either more effective than or as potent as the references. The binding of two most biologically effective compounds of zinc and mercury to calf thymus DNA has also been investigated by absorption spectra. (c) 2006 Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.ejmech.2006.09.023
dc.identifier.endpage213
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue2
dc.identifier.pmid17189664
dc.identifier.scopus2-s2.0-33847175577
dc.identifier.scopusqualityQ1
dc.identifier.startpage205
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2006.09.023
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21060
dc.identifier.volume42
dc.identifier.wosWOS:000245248300009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectantifungal
dc.subjectantimicrobial
dc.subjectequipotent
dc.subjectmetabolites
dc.subjecttridentate
dc.subjecttrigonal bipyramidal
dc.titleSynthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu